:root {
  --ink: #17211c;
  --muted: #68716b;
  --paper: #f3f0e8;
  --surface: #fbfaf6;
  --line: #d9d7ce;
  --blue: #175b79;
  --blue-deep: #103f55;
  --blue-soft: #dcebf0;
  --lime: #ddeb8b;
  --coral: #dc735b;
  --danger: #9f3c30;
  --shadow: 0 18px 60px rgba(28, 40, 34, 0.08);
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; }
body {
  margin: 0;
  color: var(--ink);
  background: var(--paper);
  font-family: "Avenir Next", "Segoe UI", sans-serif;
  line-height: 1.5;
}
button, input, select { font: inherit; }
button, label, select { -webkit-tap-highlight-color: transparent; }
button:focus-visible, input:focus-visible, select:focus-visible, summary:focus-visible, a:focus-visible {
  outline: 3px solid rgba(23, 91, 121, 0.28);
  outline-offset: 2px;
}
.site-header {
  height: 76px;
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 0 clamp(22px, 5vw, 72px);
  border-bottom: 1px solid var(--line);
}
.brand {
  display: flex;
  align-items: center;
  gap: 11px;
  color: inherit;
  text-decoration: none;
}
.brand-mark {
  width: 34px;
  height: 34px;
  border-radius: 50%;
  display: grid;
  place-items: center;
  color: white;
  background: var(--blue);
  font-family: Georgia, serif;
  font-size: 23px;
  font-style: italic;
}
.brand strong { letter-spacing: .08em; }
.brand small { margin-left: 5px; color: var(--muted); }
.header-actions { display: flex; align-items: center; gap: 24px; }
.privacy-pill {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  padding: 8px 13px;
  border-radius: 999px;
  background: #e8eddf;
  color: #496134;
  font-size: 12px;
  font-weight: 700;
}
.privacy-pill span { color: #6b8c45; font-size: 9px; }
.text-link { color: var(--ink); font-size: 13px; font-weight: 700; text-underline-offset: 4px; }
.hero {
  max-width: 1440px;
  margin: 0 auto;
  min-height: 430px;
  padding: 72px clamp(24px, 6vw, 92px) 58px;
  display: grid;
  grid-template-columns: minmax(0, 1.35fr) minmax(330px, .65fr);
  gap: clamp(40px, 8vw, 120px);
  align-items: end;
}
.eyebrow {
  margin: 0 0 16px;
  color: var(--blue);
  font-size: 11px;
  font-weight: 800;
  letter-spacing: .16em;
  text-transform: uppercase;
}
.hero h1 {
  max-width: 850px;
  margin: 0;
  font-size: clamp(52px, 6vw, 92px);
  line-height: .94;
  letter-spacing: -.055em;
  font-weight: 600;
}
.hero h1 em {
  color: var(--blue);
  font-family: Georgia, serif;
  font-weight: 500;
}
.lede {
  max-width: 720px;
  margin: 28px 0 0;
  color: #465149;
  font-size: clamp(17px, 1.5vw, 21px);
}
.hero-proof {
  padding: 28px;
  background: var(--ink);
  color: white;
  border-radius: 4px;
  box-shadow: var(--shadow);
}
.equation {
  display: flex;
  align-items: baseline;
  justify-content: space-between;
  gap: 18px;
  padding-bottom: 20px;
  border-bottom: 1px solid rgba(255,255,255,.18);
  font-family: "SFMono-Regular", Consolas, monospace;
  font-size: clamp(16px, 1.5vw, 22px);
}
.equation strong { color: var(--lime); }
.hero-proof p { margin: 20px 0 24px; color: #cbd0cc; font-size: 13px; }
.proof-row {
  display: flex;
  align-items: center;
  justify-content: space-between;
  color: var(--lime);
  font-family: "DM Mono", monospace;
  font-size: 10px;
  text-transform: uppercase;
}
.workspace {
  max-width: 1500px;
  margin: 0 auto 90px;
  display: grid;
  grid-template-columns: minmax(330px, 430px) minmax(0, 1fr);
  background: var(--surface);
  border: 1px solid var(--line);
  box-shadow: var(--shadow);
}
.setup-column { padding: 38px; border-right: 1px solid var(--line); }
.results-column { min-height: 980px; padding: 42px; background: #f8f7f2; }
.section-heading { display: flex; gap: 16px; align-items: flex-start; margin-bottom: 22px; }
.section-heading.compact { margin-top: 2px; }
.section-heading h2 { margin: 0; font-size: 20px; letter-spacing: -.025em; }
.section-heading p { margin: 3px 0 0; color: var(--muted); font-size: 12px; }
.step-number {
  display: grid;
  place-items: center;
  width: 30px;
  height: 30px;
  flex: 0 0 30px;
  border-radius: 50%;
  background: var(--blue);
  color: white;
  font: 500 10px "SFMono-Regular", Consolas, monospace;
}
.upload-grid { display: grid; gap: 11px; }
.source-switch {
  display: grid;
  grid-template-columns: 1fr 1fr;
  margin-bottom: 12px;
  border: 1px solid var(--line);
  background: #eeece5;
}
.source-switch button {
  min-height: 38px;
  color: var(--muted);
  background: transparent;
  border: 0;
  cursor: pointer;
  font-size: 10px;
  font-weight: 800;
}
.source-switch button.active { color: var(--blue-deep); background: white; }
.source-panel + .metadata-upload, .metadata-upload { margin-top: 11px; }
.file-drop {
  position: relative;
  min-height: 112px;
  padding: 20px;
  display: flex;
  flex-direction: column;
  justify-content: center;
  border: 1px dashed #aeb5af;
  background: white;
  cursor: pointer;
  transition: border-color .18s, background .18s, transform .18s;
}
.file-drop:hover, .file-drop.dragging { border-color: var(--blue); background: #f5fafb; transform: translateY(-1px); }
.file-drop.loaded { border-style: solid; border-color: #92a76f; background: #f8faef; }
.file-drop input { position: absolute; opacity: 0; pointer-events: none; }
.file-kicker { color: var(--blue); font: 500 10px "SFMono-Regular", Consolas, monospace; text-transform: uppercase; }
.file-drop strong { margin: 5px 0 3px; font-size: 14px; overflow: hidden; text-overflow: ellipsis; white-space: nowrap; }
.file-drop small { color: var(--muted); font-size: 10px; }
.upload-actions { display: flex; flex-wrap: wrap; gap: 8px; margin-top: 12px; }
.button {
  border: 0;
  min-height: 40px;
  padding: 0 16px;
  display: inline-flex;
  align-items: center;
  justify-content: center;
  cursor: pointer;
  font-size: 12px;
  font-weight: 800;
  text-decoration: none;
  transition: transform .15s, background .15s, opacity .15s;
}
.button:hover:not(:disabled) { transform: translateY(-1px); }
.button:disabled { cursor: not-allowed; opacity: .45; }
.button.primary { color: white; background: var(--blue); }
.button.primary:hover:not(:disabled) { background: var(--blue-deep); }
.button.secondary { color: var(--blue); background: var(--blue-soft); }
.button.quiet { color: var(--ink); background: transparent; border: 1px solid var(--line); }
.full-button { width: 100%; margin-top: 11px; }
.fastq-example {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 8px;
  margin-top: 8px;
}
.fastq-example small {
  grid-column: 1 / -1;
  color: var(--muted);
  font-size: 9px;
  line-height: 1.4;
}
.quant-summary { margin-top: 14px; border: 1px solid var(--line); background: white; }
.quant-heading { display: grid; grid-template-columns: 1.3fr .8fr .9fr; }
.quant-heading div { min-width: 0; padding: 11px; border-right: 1px solid var(--line); }
.quant-heading div:last-child { border-right: 0; }
.quant-heading span { display: block; color: var(--muted); font-size: 8px; text-transform: uppercase; }
.quant-heading strong { display: block; overflow: hidden; margin-top: 3px; font: 500 11px "SFMono-Regular", Consolas, monospace; text-overflow: ellipsis; white-space: nowrap; }
.compact-table { max-height: 220px; border-top: 1px solid var(--line); border-bottom: 1px solid var(--line); }
.quant-summary .upload-actions { padding: 0 10px 10px; }
.quant-summary .button { min-height: 32px; padding: 0 9px; font-size: 9px; }
.data-summary { display: grid; grid-template-columns: repeat(3, 1fr); margin-top: 16px; border: 1px solid var(--line); }
.data-summary div { padding: 12px; border-right: 1px solid var(--line); }
.data-summary div:last-child { border-right: 0; }
.data-summary strong { display: block; font: 500 15px "SFMono-Regular", Consolas, monospace; }
.data-summary span { color: var(--muted); font-size: 9px; text-transform: uppercase; letter-spacing: .08em; }
.divider { height: 1px; background: var(--line); margin: 30px 0; }
fieldset { padding: 0; margin: 0; border: 0; }
fieldset:disabled { opacity: .42; }
.field { display: grid; gap: 7px; margin-bottom: 16px; }
.field > span, .inline-field > span { font-size: 11px; font-weight: 800; }
.field small { color: var(--muted); font-weight: 500; }
select, input[type="number"], input[type="search"] {
  width: 100%;
  min-height: 42px;
  padding: 0 12px;
  color: var(--ink);
  background: white;
  border: 1px solid var(--line);
  border-radius: 0;
}
.checklist {
  max-height: 130px;
  overflow: auto;
  padding: 6px 10px;
  background: white;
  border: 1px solid var(--line);
}
.checklist label { min-height: 31px; display: flex; align-items: center; gap: 8px; font-size: 11px; }
.checklist small { color: var(--muted); }
.model-preview { padding: 14px; border-left: 3px solid var(--lime); background: #f0f2e5; }
.model-preview > span { color: var(--muted); font-size: 9px; text-transform: uppercase; }
.model-preview code { display: block; margin: 4px 0; white-space: normal; color: var(--blue-deep); font: 500 11px "SFMono-Regular", Consolas, monospace; }
.model-preview small { color: var(--muted); font-size: 9px; }
.advanced { margin: 16px 0; border-top: 1px solid var(--line); }
.advanced summary { padding: 13px 0; cursor: pointer; font-size: 11px; font-weight: 800; }
.inline-field { display: grid; grid-template-columns: 1fr 90px; gap: 12px; align-items: center; margin: 10px 0; }
.inline-field input { min-height: 36px; }
.gene-method-field { grid-template-columns: 90px minmax(0, 1fr); align-items: start; }
.gene-method-field select { min-height: 38px; padding: 0 7px; font-size: 9px; }
.toggle { display: flex; align-items: center; gap: 9px; margin: 11px 0; font-size: 11px; }
.toggle input { accent-color: var(--blue); }
.run-button { width: 100%; display: flex; align-items: center; justify-content: space-between; min-height: 52px; padding: 0 20px; }
.notice { margin: 12px 0; padding: 11px 13px; font-size: 11px; }
.notice.error { color: var(--danger); background: #f8e7e2; border-left: 3px solid var(--danger); }
.progress-wrap { margin-top: 14px; }
.progress-label { display: flex; justify-content: space-between; margin-bottom: 6px; color: var(--muted); font-size: 10px; }
progress { width: 100%; height: 6px; border: 0; appearance: none; }
progress::-webkit-progress-bar { background: var(--line); }
progress::-webkit-progress-value { background: var(--blue); }
.empty-results { max-width: 490px; margin: 160px auto 0; text-align: center; }
.empty-index {
  width: 72px;
  height: 72px;
  margin: 0 auto 28px;
  display: grid;
  place-items: center;
  border: 1px solid var(--line);
  border-radius: 50%;
  color: var(--blue);
  font: italic 500 38px Georgia, serif;
}
.empty-results h2 { margin: 0; font-size: 26px; letter-spacing: -.03em; }
.empty-results p { color: var(--muted); font-size: 13px; }
.empty-results ul { display: inline-grid; gap: 8px; padding: 0; text-align: left; list-style: none; color: #4f5a53; font-size: 11px; }
.empty-results li::before { content: "✓"; margin-right: 9px; color: var(--blue); font-weight: 800; }
.results-header { display: flex; justify-content: space-between; align-items: flex-start; gap: 24px; }
.results-header h2 { margin: 0; font-size: 31px; letter-spacing: -.04em; }
.results-header p:last-child { margin: 6px 0 0; color: var(--muted); font-size: 12px; }
.download-menu { display: flex; gap: 8px; }
.metric-grid { display: grid; grid-template-columns: repeat(4, 1fr); gap: 1px; margin: 28px 0; background: var(--line); border: 1px solid var(--line); }
.metric-grid article { min-width: 0; padding: 17px; background: white; }
.metric-grid span { color: var(--muted); font-size: 9px; text-transform: uppercase; letter-spacing: .08em; }
.metric-grid strong { display: block; margin: 4px 0 1px; font: 500 clamp(19px, 2vw, 27px) "SFMono-Regular", Consolas, monospace; }
.metric-grid small { color: var(--muted); font-size: 8px; }
.result-tabs { display: flex; gap: 22px; border-bottom: 1px solid var(--line); }
.tab { padding: 12px 0 10px; color: var(--muted); background: transparent; border: 0; border-bottom: 2px solid transparent; cursor: pointer; font-size: 11px; font-weight: 800; }
.tab.active { color: var(--blue); border-bottom-color: var(--blue); }
.tab-panel { display: none; padding-top: 22px; }
.tab-panel.active { display: block; }
.plot-card, .table-card, .diagnostic-list, .gene-note { background: white; border: 1px solid var(--line); }
.plot-card { padding: 20px; }
.plot-heading, .table-tools { display: flex; align-items: center; justify-content: space-between; gap: 20px; }
.plot-heading h3, .table-tools h3 { margin: 0; font-size: 14px; }
.plot-heading p, .table-tools p { margin: 2px 0 0; color: var(--muted); font-size: 9px; }
.legend { display: flex; align-items: center; gap: 7px; color: var(--muted); font-size: 9px; }
.legend i { width: 7px; height: 7px; border-radius: 50%; background: var(--coral); }
canvas { width: 100%; display: block; margin-top: 12px; }
.table-card { margin-top: 16px; }
.table-tools { padding: 16px 18px; border-bottom: 1px solid var(--line); }
.search { width: min(230px, 45%); }
.search input { min-height: 34px; font-size: 10px; }
.table-scroll { max-height: 500px; overflow: auto; }
table { width: 100%; border-collapse: collapse; font-size: 10px; }
th { position: sticky; top: 0; z-index: 1; padding: 10px 12px; color: var(--muted); background: #f3f2ed; text-align: left; text-transform: uppercase; letter-spacing: .06em; font-size: 8px; }
td { padding: 10px 12px; border-top: 1px solid #eceae4; white-space: nowrap; }
td.numeric, th.numeric { text-align: right; font-family: "SFMono-Regular", Consolas, monospace; }
tr.hit td:first-child { box-shadow: inset 3px 0 var(--coral); }
.badge { padding: 3px 6px; background: var(--blue-soft); color: var(--blue-deep); font-size: 8px; font-weight: 800; }
.gene-note { margin-bottom: 16px; padding: 14px 16px; color: #4f5a53; font-size: 11px; }
.diagnostic-grid { display: grid; grid-template-columns: 1.25fr .75fr; gap: 16px; }
.diagnostic-list { display: grid; align-content: start; }
.diagnostic-item { padding: 17px; border-bottom: 1px solid var(--line); }
.diagnostic-item:last-child { border-bottom: 0; }
.diagnostic-item span { color: var(--muted); font-size: 9px; text-transform: uppercase; }
.diagnostic-item strong { display: block; margin-top: 4px; font: 500 17px "SFMono-Regular", Consolas, monospace; }
.diagnostic-item p { margin: 4px 0 0; color: var(--muted); font-size: 9px; }
.principles { max-width: 1360px; margin: 0 auto 110px; padding: 0 clamp(24px, 6vw, 72px); }
.principle-grid { display: grid; grid-template-columns: repeat(4, 1fr); border-top: 1px solid var(--line); }
.principle-grid article { padding: 28px 28px 0 0; }
.principle-grid span { color: var(--blue); font: 500 10px "SFMono-Regular", Consolas, monospace; }
.principle-grid h3 { margin: 28px 0 8px; font-size: 17px; }
.principle-grid p { margin: 0; color: var(--muted); font-size: 12px; }
dialog { width: min(820px, calc(100% - 32px)); padding: 0; border: 0; color: var(--ink); box-shadow: 0 30px 100px rgba(0,0,0,.25); }
dialog::backdrop { background: rgba(23,33,28,.55); }
dialog form { padding: 28px; }
.dialog-heading { display: flex; justify-content: space-between; align-items: center; }
.dialog-heading h2 { margin: 0; }
.icon-button { width: 36px; height: 36px; border: 1px solid var(--line); background: white; cursor: pointer; font-size: 22px; }
.format-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 14px; margin: 24px 0; }
.format-grid h3 { font-size: 12px; }
pre { overflow: auto; padding: 15px; color: #dfe8e2; background: var(--ink); font: 10px/1.7 "SFMono-Regular", Consolas, monospace; }
.dialog-note { padding: 12px; background: #f0f2e5; font-size: 11px; }
.sr-only { position: absolute; width: 1px; height: 1px; padding: 0; margin: -1px; overflow: hidden; clip: rect(0,0,0,0); white-space: nowrap; border: 0; }
[hidden] { display: none !important; }

@media (max-width: 1050px) {
  .hero { grid-template-columns: 1fr; padding-top: 55px; }
  .hero-proof { max-width: 560px; }
  .workspace { margin-inline: 18px; grid-template-columns: 360px minmax(0, 1fr); }
  .setup-column, .results-column { padding: 28px; }
  .metric-grid { grid-template-columns: 1fr 1fr; }
  .diagnostic-grid { grid-template-columns: 1fr; }
}
@media (max-width: 760px) {
  .site-header { height: 66px; }
  .header-actions .text-link { display: none; }
  .privacy-pill { padding: 7px 9px; font-size: 9px; }
  .hero { min-height: auto; padding: 48px 24px; }
  .hero h1 { font-size: clamp(46px, 15vw, 68px); }
  .workspace { display: block; margin: 0 12px 70px; }
  .setup-column { border-right: 0; border-bottom: 1px solid var(--line); }
  .results-column { min-height: 700px; padding: 24px 18px; }
  .empty-results { margin-top: 70px; }
  .results-header { display: block; }
  .download-menu { margin-top: 16px; }
  .metric-grid { grid-template-columns: 1fr 1fr; }
  .result-tabs { gap: 15px; overflow-x: auto; }
  .plot-card { padding: 14px; }
  .plot-heading { align-items: flex-start; }
  .table-tools { align-items: flex-start; }
  .principle-grid { grid-template-columns: 1fr; }
  .format-grid { grid-template-columns: 1fr; }
}