# Ontology over the POTS phenotyping vocabulary. # # POTS is the root of the evidence graph: every literature link points toward # it (test -> cause, treatment -> cause, cause -> POTS, condition -> POTS). The # questions those links answer are in docs/COMPETENCY_QUESTIONS.md. # # Two kinds of edge live here: # # 1. Taxonomy (`is_a`, provenance 'taxonomy'): what kind of thing each topic # is, for mapping to OMOP domains. Hand-maintained below. Structure, not a # literature claim. # # 2. Literature links (every other predicate): generated from the quoted # claims in config/relation_excerpts.yaml by scripts/build_relations.py. # Do not edit that block by hand; add or change a claim and regenerate. # Provenance names the seed papers whose passages back the link. # # The resolved OMOP graph built by `pots-phenotyping ontology` is kept apart in # its own tables and never merged into these edges. # # Predicates. Only is_a is subsumption; part_of is transitive but not is_a. The # rest are domain relations and must not be traversed as if they were is_a. # # is_a - what kind of thing a topic is. Transitive. # part_of - component of a composite test or battery. # evidence_for - a test supplies objective evidence for a cause, # for POTS, or for a linked condition. # indicates - prescribing a treatment is weak evidence that a # clinician suspected that cause or condition. # treats - therapeutic target. # measures - the physiological quantity a test quantifies. # associated_with - co-occurrence, no causal claim. # proposed_mechanism_of - a cause proposed to produce POTS, or a condition # proposed to produce a cause. # trigger_of - exposure or event preceding onset. # differential_diagnosis_of - must be excluded before the diagnosis stands. predicates: is_a: {transitive: true, subsumption: true, inverse: subsumes} part_of: {transitive: true, subsumption: false, inverse: has_part} evidence_for: {transitive: false, subsumption: false, inverse: assessed_by} indicates: {transitive: false, subsumption: false, inverse: indicated_by} treats: {transitive: false, subsumption: false, inverse: treated_by} measures: {transitive: false, subsumption: false, inverse: measured_by} associated_with: {transitive: false, subsumption: false, inverse: associated_with, symmetric: true} proposed_mechanism_of: {transitive: false, subsumption: false, inverse: has_proposed_mechanism} trigger_of: {transitive: false, subsumption: false, inverse: triggered_by} differential_diagnosis_of: {transitive: false, subsumption: false, inverse: has_differential_diagnosis} # Abstract nodes: classes for the taxonomy, quantities that tests measure, and # test batteries. Nothing is harvested for them. classes: - {id: pots, label: 'Postural orthostatic tachycardia syndrome', kind: disorder} - {id: pots_phenotype_axis, label: 'POTS phenotyping topics', kind: root} - {id: mechanistic_phenotype, label: 'Mechanistic phenotype', kind: class} - {id: objective_evidence, label: 'Objective evidence source', kind: class} - {id: clinical_context, label: 'Clinical context', kind: class} - {id: therapeutic_proxy, label: 'Therapeutic proxy', kind: class} - {id: autonomic_function_testing, label: 'Autonomic function testing', kind: procedure_class} - {id: autonomic_reflex_screen, label: 'Autonomic reflex screen', kind: test_battery} - {id: orthostatic_challenge_testing, label: 'Orthostatic challenge testing', kind: test_battery} - {id: sudomotor_assessment, label: 'Sudomotor assessment', kind: procedure_class} - {id: neurochemical_assessment, label: 'Sympathetic neurochemical assessment', kind: procedure_class} - {id: volume_assessment, label: 'Intravascular volume assessment', kind: procedure_class} - {id: structural_nerve_assessment, label: 'Structural peripheral nerve assessment', kind: procedure_class} - {id: cerebrovascular_assessment, label: 'Cerebrovascular assessment', kind: procedure_class} - {id: immunological_assessment, label: 'Immunological assessment', kind: procedure_class} - {id: vasoconstrictor_agent, label: 'Vasoconstrictor agent', kind: drug_class} - {id: negative_chronotrope, label: 'Negative chronotropic agent', kind: drug_class} - {id: volume_expander, label: 'Volume expanding agent', kind: drug_class} - {id: sympatholytic_agent, label: 'Sympatholytic agent', kind: drug_class} - {id: cholinergic_agent, label: 'Cholinergic agent', kind: drug_class} - {id: immunomodulator, label: 'Immunomodulatory agent', kind: drug_class} - {id: nonpharmacologic_intervention, label: 'Non-pharmacological intervention', kind: intervention_class} - {id: orthostatic_heart_rate_increment, label: 'Orthostatic heart rate increment', kind: quantity} - {id: upright_plasma_norepinephrine, label: 'Upright plasma norepinephrine', kind: quantity} - {id: intravascular_volume, label: 'Intravascular volume', kind: quantity} - {id: sweat_output, label: 'Sweat output', kind: quantity} - {id: nerve_fiber_density, label: 'Intraepidermal nerve fibre density', kind: quantity} - {id: cerebral_perfusion, label: 'Cerebral perfusion', kind: quantity} - {id: aerobic_capacity, label: 'Aerobic capacity', kind: quantity} - {id: differential_condition, label: 'Must be ruled out before diagnosis', kind: class} - {id: onset_trigger, label: 'Onset trigger', kind: class} - {id: co_occurring_condition, label: 'Co-occurring condition', kind: class} - {id: cardiac_imaging, label: 'Cardiac imaging', kind: procedure_class} - {id: sensory_nerve_assessment, label: 'Sensory nerve function assessment', kind: procedure_class} - {id: neuromodulation, label: 'Neuromodulation', kind: intervention_class} - {id: antihistamine_agent, label: 'Antihistamine or mast cell stabiliser', kind: drug_class} - {id: prokinetic_agent, label: 'Prokinetic agent', kind: drug_class} - {id: sedative_agent, label: 'Sedative agent', kind: drug_class} relations: # ---- taxonomy (is_a), hand-maintained ------------------------------------ - [antihistamine_therapy, is_a, antihistamine_agent, 'taxonomy'] - [autonomic_reflex_screen, is_a, autonomic_function_testing, 'taxonomy'] - [heart_rate_variability, is_a, autonomic_function_testing, 'taxonomy'] - [muscle_sympathetic_nerve_activity, is_a, autonomic_function_testing, 'taxonomy'] - [orthostatic_challenge_testing, is_a, autonomic_function_testing, 'taxonomy'] - [sudomotor_assessment, is_a, autonomic_function_testing, 'taxonomy'] - [valsalva_maneuver, is_a, autonomic_function_testing, 'taxonomy'] - [cardiac_mri, is_a, cardiac_imaging, 'taxonomy'] - [cerebral_blood_flow_measurement, is_a, cerebrovascular_assessment, 'taxonomy'] - [end_tidal_co2, is_a, cerebrovascular_assessment, 'taxonomy'] - [pyridostigmine_therapy, is_a, cholinergic_agent, 'taxonomy'] - [co_occurring_condition, is_a, clinical_context, 'taxonomy'] - [differential_condition, is_a, clinical_context, 'taxonomy'] - [onset_trigger, is_a, clinical_context, 'taxonomy'] - [anxiety_depression, is_a, co_occurring_condition, 'taxonomy'] - [chronic_migraine, is_a, co_occurring_condition, 'taxonomy'] - [endometriosis, is_a, co_occurring_condition, 'taxonomy'] - [fibromyalgia, is_a, co_occurring_condition, 'taxonomy'] - [functional_neurological_disorder, is_a, co_occurring_condition, 'taxonomy'] - [gi_dysmotility, is_a, co_occurring_condition, 'taxonomy'] - [hypermobility_heds, is_a, co_occurring_condition, 'taxonomy'] - [iron_deficiency, is_a, co_occurring_condition, 'taxonomy'] - [long_covid, is_a, co_occurring_condition, 'taxonomy'] - [mast_cell_activation, is_a, co_occurring_condition, 'taxonomy'] - [me_cfs, is_a, co_occurring_condition, 'taxonomy'] - [neurodevelopmental_disorder, is_a, co_occurring_condition, 'taxonomy'] - [sleep_disturbance, is_a, co_occurring_condition, 'taxonomy'] - [small_fiber_neuropathy_dx, is_a, co_occurring_condition, 'taxonomy'] - [systemic_autoimmune_disease, is_a, co_occurring_condition, 'taxonomy'] - [arrhythmia_differential, is_a, differential_condition, 'taxonomy'] - [differential_syncope_oh, is_a, differential_condition, 'taxonomy'] - [medication_induced_tachycardia, is_a, differential_condition, 'taxonomy'] - [secondary_sinus_tachycardia, is_a, differential_condition, 'taxonomy'] - [structural_cardiopulmonary_disease, is_a, differential_condition, 'taxonomy'] - [autonomic_autoantibody_assay, is_a, immunological_assessment, 'taxonomy'] - [immunomodulatory_therapy, is_a, immunomodulator, 'taxonomy'] - [autoimmune_evidence, is_a, mechanistic_phenotype, 'taxonomy'] - [cerebral_hypoperfusion_evidence, is_a, mechanistic_phenotype, 'taxonomy'] - [deconditioning_evidence, is_a, mechanistic_phenotype, 'taxonomy'] - [hyperadrenergic_evidence, is_a, mechanistic_phenotype, 'taxonomy'] - [hypovolemic_evidence, is_a, mechanistic_phenotype, 'taxonomy'] - [neuropathic_evidence, is_a, mechanistic_phenotype, 'taxonomy'] - [postinfectious_evidence, is_a, mechanistic_phenotype, 'taxonomy'] - [beta_blocker_therapy, is_a, negative_chronotrope, 'taxonomy'] - [ivabradine_therapy, is_a, negative_chronotrope, 'taxonomy'] - [plasma_catecholamine_assay, is_a, neurochemical_assessment, 'taxonomy'] - [regional_norepinephrine_spillover, is_a, neurochemical_assessment, 'taxonomy'] - [auricular_vagus_nerve_stimulation, is_a, neuromodulation, 'taxonomy'] - [compression_therapy, is_a, nonpharmacologic_intervention, 'taxonomy'] - [exercise_reconditioning, is_a, nonpharmacologic_intervention, 'taxonomy'] - [lifestyle_modification, is_a, nonpharmacologic_intervention, 'taxonomy'] - [offending_medication_withdrawal, is_a, nonpharmacologic_intervention, 'taxonomy'] - [physical_countermaneuvers, is_a, nonpharmacologic_intervention, 'taxonomy'] - [ambulatory_monitoring, is_a, objective_evidence, 'taxonomy'] - [autonomic_function_testing, is_a, objective_evidence, 'taxonomy'] - [cardiac_imaging, is_a, objective_evidence, 'taxonomy'] - [cardiopulmonary_exercise_test, is_a, objective_evidence, 'taxonomy'] - [cerebrovascular_assessment, is_a, objective_evidence, 'taxonomy'] - [genetic_testing, is_a, objective_evidence, 'taxonomy'] - [immunological_assessment, is_a, objective_evidence, 'taxonomy'] - [neurochemical_assessment, is_a, objective_evidence, 'taxonomy'] - [sensory_nerve_assessment, is_a, objective_evidence, 'taxonomy'] - [structural_nerve_assessment, is_a, objective_evidence, 'taxonomy'] - [volume_assessment, is_a, objective_evidence, 'taxonomy'] - [adolescent_growth_spurt, is_a, onset_trigger, 'taxonomy'] - [hormonal_transition_onset, is_a, onset_trigger, 'taxonomy'] - [physical_trauma_onset, is_a, onset_trigger, 'taxonomy'] - [post_vaccination_onset, is_a, onset_trigger, 'taxonomy'] - [prolonged_bed_rest, is_a, onset_trigger, 'taxonomy'] - [surgery_onset, is_a, onset_trigger, 'taxonomy'] - [active_stand_test, is_a, orthostatic_challenge_testing, 'taxonomy'] - [head_up_tilt_test, is_a, orthostatic_challenge_testing, 'taxonomy'] - [clinical_context, is_a, pots_phenotype_axis, 'taxonomy'] - [mechanistic_phenotype, is_a, pots_phenotype_axis, 'taxonomy'] - [objective_evidence, is_a, pots_phenotype_axis, 'taxonomy'] - [therapeutic_proxy, is_a, pots_phenotype_axis, 'taxonomy'] - [prokinetic_therapy, is_a, prokinetic_agent, 'taxonomy'] - [phenobarbital_therapy, is_a, sedative_agent, 'taxonomy'] - [quantitative_sensory_testing, is_a, sensory_nerve_assessment, 'taxonomy'] - [skin_biopsy_ienfd, is_a, structural_nerve_assessment, 'taxonomy'] - [qsart_sudomotor_testing, is_a, sudomotor_assessment, 'taxonomy'] - [thermoregulatory_sweat_test, is_a, sudomotor_assessment, 'taxonomy'] - [beta_blocker_therapy, is_a, sympatholytic_agent, 'taxonomy'] - [central_sympatholytic_therapy, is_a, sympatholytic_agent, 'taxonomy'] - [antihistamine_agent, is_a, therapeutic_proxy, 'taxonomy'] - [cholinergic_agent, is_a, therapeutic_proxy, 'taxonomy'] - [immunomodulator, is_a, therapeutic_proxy, 'taxonomy'] - [negative_chronotrope, is_a, therapeutic_proxy, 'taxonomy'] - [neuromodulation, is_a, therapeutic_proxy, 'taxonomy'] - [nonpharmacologic_intervention, is_a, therapeutic_proxy, 'taxonomy'] - [prokinetic_agent, is_a, therapeutic_proxy, 'taxonomy'] - [sedative_agent, is_a, therapeutic_proxy, 'taxonomy'] - [serotonergic_therapy, is_a, therapeutic_proxy, 'taxonomy'] - [sympatholytic_agent, is_a, therapeutic_proxy, 'taxonomy'] - [vasoconstrictor_agent, is_a, therapeutic_proxy, 'taxonomy'] - [volume_expander, is_a, therapeutic_proxy, 'taxonomy'] - [droxidopa_therapy, is_a, vasoconstrictor_agent, 'taxonomy'] - [midodrine_therapy, is_a, vasoconstrictor_agent, 'taxonomy'] - [plasma_blood_volume_assay, is_a, volume_assessment, 'taxonomy'] - [renin_aldosterone_assay, is_a, volume_assessment, 'taxonomy'] - [urine_sodium_24h, is_a, volume_assessment, 'taxonomy'] - [volume_expansion_therapy, is_a, volume_expander, 'taxonomy'] # >>> generated from config/relation_excerpts.yaml by scripts/build_relations.py; do not edit # proposed_mechanism_of - [anxiety_depression, proposed_mechanism_of, hyperadrenergic_evidence, 'pmid40276022; pmid39540412; pmid35802513; pmid33178533'] - [anxiety_depression, proposed_mechanism_of, pots, 'pmid40276022; pmid40763323; pmid39540412'] - [autoimmune_evidence, proposed_mechanism_of, hyperadrenergic_evidence, 'pmid40537187; pmid38173801; pmid37999672; pmid37631004; pmid36873318; pmid36852364; pmid35853576; pmid35118574; pmid34409582; pmid33505857; pmid32743496; pmid31547749; pmid29682372; pmid24572257; pmid37009342; pmid34055446; pmid33677650; pmid29102451'] - [autoimmune_evidence, proposed_mechanism_of, hypovolemic_evidence, 'pmid33677650; pmid37393658'] - [autoimmune_evidence, proposed_mechanism_of, neuropathic_evidence, 'pmid36349067; pmid33677650; pmid29864098; pmid21802629; pmid24386408'] - [autoimmune_evidence, proposed_mechanism_of, postinfectious_evidence, 'pmid38240001; pmid36614874; pmid33262898; pmid41275041; pmid40692561; pmid38673062; pmid38173801; pmid37435242; pmid37009342; pmid36947108; pmid36852364; pmid36732397; pmid35853576; pmid35852546; pmid35725868; pmid34729276; pmid34144933; pmid33968543; pmid33935300; pmid33723532; pmid32848537; pmid29523389; pmid24386408; pmid19058765'] - [autoimmune_evidence, proposed_mechanism_of, pots, 'pmid42688561; pmid41446482; pmid41275041; pmid41089328; pmid41069916; pmid41020219; pmid40776616; pmid40763323; pmid40734755; pmid40537187; pmid40432440; pmid39852767; pmid39597891; pmid39559520; pmid39355826; pmid39202605; pmid39200375; pmid38900132; pmid38736760; pmid38673062; pmid38348221; pmid38240001; pmid38173801; pmid37999672; pmid37981644; pmid37822957; pmid37654428; pmid37631004; pmid37519618; pmid37510775; pmid37508589; pmid37435242; pmid37393658; pmid37204997; pmid37009342; pmid36947108; pmid36938206; pmid36873318; pmid36852364; pmid36816268; pmid36414707; pmid36349067; pmid36339677; pmid36075372; pmid36074973; pmid36000360; pmid35992935; pmid35870086; pmid35853576; pmid35852546; pmid35766055; pmid35725868; pmid35680184; pmid35355961; pmid35288409; pmid35269395; pmid35118574; pmid34928881; pmid34821709; pmid34729276; pmid34471867; pmid34409582; pmid34390682; pmid34275953; pmid34265539; pmid34246578; pmid34144933; pmid34127505; pmid34117922; pmid34055446; pmid34035985; pmid33968543; pmid33935300; pmid33886735; pmid33723532; pmid33677650; pmid33562074; pmid33505857; pmid33316414; pmid33262898; pmid33178533; pmid32974246; pmid32848537; pmid32750291; pmid32743496; pmid32655482; pmid32477718; pmid32321428; pmid31547756; pmid31547749; pmid31495251; pmid31139694; pmid31001074; pmid30883381; pmid30372565; pmid29864098; pmid29687025; pmid29618472; pmid29523389; pmid29343965; pmid27702852; pmid26198889; pmid25087056; pmid24819031; pmid24572257; pmid24102827; pmid23562385; pmid23002038; pmid19058765; pmid42605371; pmid42512077; pmid42037722; pmid41103515; pmid40692561; pmid39447442; pmid38464711; pmid38396973; pmid37400156; pmid37388279; pmid37378800; pmid37255928; pmid37248893; pmid36732397; pmid36718484; pmid36518330; pmid36509178; pmid36475233; pmid35937046; pmid35062788; pmid34993884; pmid34866935; pmid33382525; pmid29682372; pmid27638661; pmid24386408; pmid21802629'] - [cerebral_hypoperfusion_evidence, proposed_mechanism_of, hyperadrenergic_evidence, 'pmid24711524'] - [cerebral_hypoperfusion_evidence, proposed_mechanism_of, pots, 'pmid41859298; pmid41103515; pmid40601666; pmid39895557; pmid39857750; pmid39597891; pmid39544990; pmid39297132; pmid37443510; pmid33677650; pmid33352894; pmid29960989; pmid24711524; pmid42605371; pmid42299168; pmid42114076; pmid41740821; pmid41602336; pmid41357159; pmid39297140; pmid38490814; pmid38390594; pmid37227184; pmid35307584; pmid34746821; pmid25002851; pmid23390443; pmid22783324'] - [deconditioning_evidence, proposed_mechanism_of, pots, 'pmid42037722; pmid41976810; pmid41446482; pmid41166031; pmid40763323; pmid40538940; pmid39678714; pmid39597891; pmid39559520; pmid36387679; pmid36339677; pmid36043022; pmid35853576; pmid35355961; pmid34987818; pmid34331416; pmid34144933; pmid32848537; pmid32494413; pmid32321428; pmid32222376; pmid31798399; pmid30001836; pmid25487551; pmid24819031; pmid22889291; pmid20579544; pmid19207771; pmid18704621; pmid39297132; pmid35647216; pmid35557616; pmid34265539; pmid33490373; pmid33316414; pmid33178533; pmid29343965; pmid25168872; pmid21906029; pmid21690484'] - [gi_dysmotility, proposed_mechanism_of, pots, 'pmid29549458; pmid29343965'] - [hormonal_transition_onset, proposed_mechanism_of, pots, 'pmid31798399'] - [hyperadrenergic_evidence, proposed_mechanism_of, cerebral_hypoperfusion_evidence, 'pmid41357159; pmid24982638'] - [hyperadrenergic_evidence, proposed_mechanism_of, hypovolemic_evidence, 'pmid34268642'] - [hyperadrenergic_evidence, proposed_mechanism_of, postinfectious_evidence, 'pmid37009342'] - [hyperadrenergic_evidence, proposed_mechanism_of, pots, 'pmid42299168; pmid42060631; pmid41767063; pmid41538594; pmid41533304; pmid41314719; pmid41163092; pmid41103515; pmid41020219; pmid40776616; pmid40734755; pmid40626134; pmid40601666; pmid40537187; pmid40507411; pmid40432440; pmid40294227; pmid40276022; pmid39768649; pmid39582682; pmid39355826; pmid39297132; pmid39268060; pmid39165715; pmid39109428; pmid38937334; pmid38673062; pmid38336892; pmid38173801; pmid38168762; pmid37999672; pmid37705599; pmid37654428; pmid37519618; pmid37508741; pmid37508589; pmid37378164; pmid37248893; pmid37209261; pmid37009342; pmid36938206; pmid36873318; pmid36781629; pmid36339677; pmid36292504; pmid36187012; pmid36111700; pmid36000360; pmid35992935; pmid35853576; pmid35742222; pmid35733987; pmid35351159; pmid35288409; pmid35232225; pmid35127870; pmid35118574; pmid34928881; pmid34390682; pmid34327047; pmid34144933; pmid33677650; pmid33423527; pmid33178533; pmid33150760; pmid32974246; pmid32848537; pmid32823577; pmid32750291; pmid32743496; pmid32673517; pmid32612820; pmid32494413; pmid32222376; pmid31888497; pmid31798399; pmid31788462; pmid31547749; pmid31384930; pmid31307619; pmid31156539; pmid30372565; pmid29549458; pmid29343965; pmid29102451; pmid27660311; pmid27625098; pmid26610893; pmid26241226; pmid26198889; pmid25980576; pmid25811760; pmid25792354; pmid25483980; pmid25204388; pmid25180969; pmid25120493; pmid24982638; pmid24819031; pmid24711524; pmid24002370; pmid23862007; pmid23720636; pmid23283362; pmid23244360; pmid21977261; pmid21906029; pmid21266211; pmid19289653; pmid19207771; pmid16943900; pmid12416949; pmid11458707; pmid11201632; pmid9868411; pmid42605371; pmid42369281; pmid42037960; pmid41976810; pmid41357159; pmid40310095; pmid39559520; pmid39540412; pmid39463038; pmid39395208; pmid39297140; pmid39202605; pmid39076856; pmid38962840; pmid38585862; pmid38526146; pmid37631004; pmid37435242; pmid36852364; pmid36818521; pmid36414707; pmid36074973; pmid35802513; pmid34746821; pmid34729276; pmid34634682; pmid34409582; pmid34268642; pmid34055686; pmid34035985; pmid33926653; pmid33505857; pmid33490373; pmid33486983; pmid33316414; pmid33114659; pmid32880754; pmid32284866; pmid31780890; pmid30879357; pmid29864098; pmid29523389; pmid27938459; pmid25713509; pmid25653673; pmid24572257; pmid22783324; pmid21802629; pmid21751966; pmid19324216; pmid17709712; pmid11206727; pmid11198483'] - [hypermobility_heds, proposed_mechanism_of, hyperadrenergic_evidence, 'pmid25713509'] - [hypermobility_heds, proposed_mechanism_of, pots, 'pmid39582682; pmid35620060; pmid19946638; pmid34055418'] - [hypovolemic_evidence, proposed_mechanism_of, cerebral_hypoperfusion_evidence, 'pmid40601666; pmid34821709; pmid33677650'] - [hypovolemic_evidence, proposed_mechanism_of, deconditioning_evidence, 'pmid25168872'] - [hypovolemic_evidence, proposed_mechanism_of, hyperadrenergic_evidence, 'pmid35355961; pmid34821709; pmid29523389; pmid25713509; pmid23217691; pmid40027266'] - [hypovolemic_evidence, proposed_mechanism_of, pots, 'pmid42342500; pmid42299168; pmid42037722; pmid41446482; pmid41357159; pmid40734755; pmid40626134; pmid40601666; pmid39614968; pmid39268060; pmid39200375; pmid38673062; pmid38328599; pmid38171114; pmid38168762; pmid37519618; pmid37508589; pmid37443510; pmid37435242; pmid37393658; pmid37009342; pmid36938206; pmid36339677; pmid35853576; pmid35742222; pmid35355961; pmid34866935; pmid34821709; pmid34746821; pmid34327047; pmid34144933; pmid34055686; pmid33926653; pmid32974246; pmid32655482; pmid32612820; pmid32112609; pmid31384930; pmid30001836; pmid29864098; pmid29549458; pmid29523389; pmid29102451; pmid27660311; pmid27625098; pmid25980576; pmid25792354; pmid25713509; pmid24982638; pmid24819031; pmid22721633; pmid22247480; pmid21266211; pmid20579544; pmid20479333; pmid11201632; pmid42591853; pmid42114076; pmid42037960; pmid41976810; pmid41703216; pmid40944681; pmid39895557; pmid39559520; pmid39297140; pmid38392604; pmid38287400; pmid38173801; pmid36000360; pmid34268642; pmid33490373; pmid33316414; pmid32983103; pmid32494413; pmid31798399; pmid31780890; pmid31405524; pmid29876157; pmid29682372; pmid29451148; pmid27936059; pmid26814068; pmid26198889; pmid25483980; pmid25474569; pmid25168872; pmid23753844; pmid16262605; pmid9244228'] - [iron_deficiency, proposed_mechanism_of, pots, 'pmid32974246; pmid23720007; pmid39559520'] - [long_covid, proposed_mechanism_of, autoimmune_evidence, 'pmid39200375; pmid37435242; pmid36947108; pmid36852364; pmid35725868; pmid41089328; pmid40692561; pmid38673062; pmid37388279; pmid37255928; pmid36509178; pmid35852546; pmid35288409; pmid34992725; pmid34821709; pmid33935300; pmid33262898'] - [long_covid, proposed_mechanism_of, cerebral_hypoperfusion_evidence, 'pmid39857750'] - [long_covid, proposed_mechanism_of, deconditioning_evidence, 'pmid33860871'] - [long_covid, proposed_mechanism_of, hyperadrenergic_evidence, 'pmid35853576; pmid41859298; pmid38526146; pmid33860871'] - [long_covid, proposed_mechanism_of, hypovolemic_evidence, 'pmid39200375; pmid38392604'] - [long_covid, proposed_mechanism_of, neuropathic_evidence, 'pmid36938206; pmid36718227; pmid35355961; pmid39741599'] - [long_covid, proposed_mechanism_of, postinfectious_evidence, 'pmid41020219; pmid36518330; pmid42245008; pmid40692561; pmid37009342; pmid36947108; pmid36614874; pmid35853576; pmid35355961; pmid35288409; pmid34992725; pmid34729276; pmid33935300; pmid33262898'] - [long_covid, proposed_mechanism_of, pots, 'pmid41275041; pmid41020219; pmid39597891; pmid39202605; pmid39200375; pmid38673062; pmid37435242; pmid37204997; pmid37009342; pmid36938206; pmid36518330; pmid36339677; pmid35853576; pmid35852546; pmid35355961; pmid35269395; pmid34992725; pmid34729276; pmid33935300; pmid33262898; pmid42605371; pmid42512077; pmid42245008; pmid40692561; pmid39741599; pmid39559520; pmid39076856; pmid38526146; pmid38392604; pmid38173801; pmid37670400; pmid36947108; pmid36718227; pmid36614874; pmid35725868; pmid35288409; pmid34821709; pmid33860871; pmid32970212'] - [mast_cell_activation, proposed_mechanism_of, hyperadrenergic_evidence, 'pmid39559520; pmid38526146; pmid37255928; pmid29326369; pmid24819031'] - [mast_cell_activation, proposed_mechanism_of, hypovolemic_evidence, 'pmid37241210'] - [mast_cell_activation, proposed_mechanism_of, postinfectious_evidence, 'pmid36981522'] - [mast_cell_activation, proposed_mechanism_of, pots, 'pmid41668453; pmid40729147; pmid39559520; pmid39165715; pmid38526146; pmid35062788; pmid34821709; pmid34398691; pmid32974246; pmid29326369; pmid15710782; pmid38348221; pmid36969375; pmid29523389; pmid24819031'] - [me_cfs, proposed_mechanism_of, pots, 'pmid37241210'] - [neuropathic_evidence, proposed_mechanism_of, hyperadrenergic_evidence, 'pmid30879357; pmid12577219'] - [neuropathic_evidence, proposed_mechanism_of, postinfectious_evidence, 'pmid37822957; pmid35355961'] - [neuropathic_evidence, proposed_mechanism_of, pots, 'pmid42342500; pmid42037722; pmid41767063; pmid41675297; pmid41446482; pmid41275041; pmid41020219; pmid40734755; pmid40608783; pmid39559520; pmid39355826; pmid39268060; pmid39200375; pmid39109428; pmid38937334; pmid38673062; pmid38390594; pmid37968647; pmid37654428; pmid37519618; pmid37508589; pmid36938206; pmid36349067; pmid36111700; pmid36000360; pmid35992935; pmid34928881; pmid34674068; pmid34144933; pmid34127505; pmid33860871; pmid33764697; pmid33677650; pmid33178533; pmid33150760; pmid32655482; pmid32477718; pmid32284866; pmid32222376; pmid31798399; pmid29864098; pmid29549458; pmid29523389; pmid29102451; pmid27938459; pmid27660311; pmid26610893; pmid26198889; pmid25120493; pmid24982638; pmid24819031; pmid24386408; pmid23862007; pmid23244360; pmid23217691; pmid22889291; pmid22783324; pmid21802629; pmid20185461; pmid20035362; pmid19207771; pmid17898925; pmid17352367; pmid16943900; pmid12577219; pmid11408377; pmid11018167; pmid9868411; pmid9848003; pmid8423877; pmid39741599; pmid38392604; pmid37435242; pmid35355961; pmid34471867; pmid34055418; pmid33490373; pmid33316414; pmid32848537; pmid30879357; pmid29876157; pmid19687022; pmid11198483'] - [post_vaccination_onset, proposed_mechanism_of, autoimmune_evidence, 'pmid35870086; pmid33968543; pmid36718484; pmid36475233; pmid36075372; pmid33562074; pmid31001074'] - [post_vaccination_onset, proposed_mechanism_of, neuropathic_evidence, 'pmid41275041'] - [post_vaccination_onset, proposed_mechanism_of, pots, 'pmid41020219; pmid38673062; pmid36475233; pmid35870086; pmid35062788; pmid33968543; pmid31001074; pmid41275041; pmid37009342; pmid36852364; pmid36718484; pmid36075372; pmid33562074; pmid24102827'] - [postinfectious_evidence, proposed_mechanism_of, autoimmune_evidence, 'pmid40977456; pmid40692561; pmid38673062; pmid37435242; pmid36947108; pmid36852364; pmid36732397; pmid35853576; pmid35725868; pmid34265539; pmid33935300; pmid31495251; pmid31001074; pmid24572257; pmid19058765; pmid41275041; pmid38173801; pmid37009342; pmid36614874; pmid35288409; pmid34729276; pmid34144933; pmid32848537; pmid29523389; pmid24386408'] - [postinfectious_evidence, proposed_mechanism_of, deconditioning_evidence, 'pmid35853576'] - [postinfectious_evidence, proposed_mechanism_of, hyperadrenergic_evidence, 'pmid37009342; pmid36718227; pmid35853576; pmid36852364; pmid34729276'] - [postinfectious_evidence, proposed_mechanism_of, neuropathic_evidence, 'pmid37822957; pmid36938206; pmid36718227; pmid35355961; pmid24386408; pmid20035362'] - [postinfectious_evidence, proposed_mechanism_of, pots, 'pmid42512077; pmid41275041; pmid41020219; pmid40977456; pmid40763323; pmid39857750; pmid39559520; pmid39202605; pmid39200375; pmid38673062; pmid38390594; pmid38240001; pmid37822957; pmid37654428; pmid37435242; pmid37209261; pmid37009342; pmid36947108; pmid36938206; pmid36852364; pmid36732397; pmid36518330; pmid36414707; pmid35853576; pmid35725868; pmid35680184; pmid35288409; pmid35269395; pmid35181863; pmid34821709; pmid34390682; pmid34265539; pmid34144933; pmid34127505; pmid33983522; pmid33968543; pmid33935300; pmid33927679; pmid33860871; pmid33723532; pmid33562074; pmid33316414; pmid33262898; pmid32848537; pmid31495251; pmid31001074; pmid24572257; pmid23002038; pmid20035362; pmid19058765; pmid42524295; pmid42245008; pmid41767063; pmid40692561; pmid38173801; pmid36718227; pmid36614874; pmid35852546; pmid35355961; pmid35118574; pmid34992725; pmid34729276; pmid29523389; pmid27702852; pmid26198889; pmid24386408'] - [prolonged_bed_rest, proposed_mechanism_of, deconditioning_evidence, 'pmid42458878; pmid35355961; pmid34987818; pmid24819031; pmid22889291; pmid34265539'] - [prolonged_bed_rest, proposed_mechanism_of, hypovolemic_evidence, 'pmid34144933'] - [prolonged_bed_rest, proposed_mechanism_of, pots, 'pmid41446482; pmid41275041; pmid34987818; pmid24819031; pmid40538940; pmid30001836; pmid22889291; pmid18704621'] - [sleep_disturbance, proposed_mechanism_of, hyperadrenergic_evidence, 'pmid35303039'] - [sleep_disturbance, proposed_mechanism_of, pots, 'pmid25474569; pmid42254140; pmid35303039'] - [small_fiber_neuropathy_dx, proposed_mechanism_of, neuropathic_evidence, 'pmid41675297; pmid33764697; pmid16943900'] - [small_fiber_neuropathy_dx, proposed_mechanism_of, pots, 'pmid41446482; pmid41275041; pmid36938206; pmid33860871; pmid39741599; pmid38392604; pmid34471867; pmid33764697; pmid24386408; pmid16943900'] - [surgery_onset, proposed_mechanism_of, deconditioning_evidence, 'pmid22889291'] - [surgery_onset, proposed_mechanism_of, pots, 'pmid22889291'] - [systemic_autoimmune_disease, proposed_mechanism_of, autoimmune_evidence, 'pmid41446482; pmid36816268; pmid34144933; pmid33562074; pmid29864098'] - [systemic_autoimmune_disease, proposed_mechanism_of, neuropathic_evidence, 'pmid29864098'] - [systemic_autoimmune_disease, proposed_mechanism_of, pots, 'pmid41446482; pmid34035985; pmid36816268; pmid35288409; pmid34144933; pmid33562074; pmid29864098'] # evidence_for - [active_stand_test, evidence_for, hyperadrenergic_evidence, 'pmid40537187; pmid38937334; pmid37508589; pmid35733987'] - [active_stand_test, evidence_for, hypovolemic_evidence, 'pmid23538032'] - [active_stand_test, evidence_for, long_covid, 'pmid36611357; pmid36518330; pmid36298551; pmid33935300'] - [active_stand_test, evidence_for, postinfectious_evidence, 'pmid36611357; pmid33935300'] - [active_stand_test, evidence_for, pots, 'pmid41713697; pmid41584279; pmid40970182; pmid40694349; pmid40537187; pmid40533427; pmid40432440; pmid40310134; pmid40125494; pmid38937334; pmid38074226; pmid38033543; pmid37391116; pmid37378164; pmid37255912; pmid36818521; pmid36611357; pmid35288409; pmid35224842; pmid34987818; pmid34055686; pmid33935300; pmid33723532; pmid33423527; pmid31780890; pmid31139694; pmid31118385; pmid30560108; pmid30505831; pmid26033944; pmid25474569; pmid24227635; pmid23862007; pmid23283362; pmid42387884; pmid41163092; pmid39592549; pmid38176772; pmid36518330; pmid35733987; pmid35673757; pmid35035423; pmid24495468'] - [ambulatory_monitoring, evidence_for, differential_syncope_oh, 'pmid35372154'] - [ambulatory_monitoring, evidence_for, hyperadrenergic_evidence, 'pmid38937334'] - [ambulatory_monitoring, evidence_for, pots, 'pmid38176772; pmid35307584; pmid39109119; pmid32846397; pmid32477718; pmid23270259'] - [autonomic_autoantibody_assay, evidence_for, autoimmune_evidence, 'pmid38736760; pmid38673062; pmid34471867; pmid34409582; pmid34275953; pmid29618472; pmid24572257; pmid40537187; pmid40432440; pmid39202605; pmid37654428; pmid35269395; pmid34117922; pmid33562074; pmid32750291; pmid32743496; pmid31547756; pmid31495251; pmid31139694; pmid29687025; pmid27702852; pmid23002038'] - [autonomic_autoantibody_assay, evidence_for, hyperadrenergic_evidence, 'pmid40537187'] - [autonomic_autoantibody_assay, evidence_for, long_covid, 'pmid39202605; pmid37654428; pmid36832445'] - [autonomic_autoantibody_assay, evidence_for, neuropathic_evidence, 'pmid34471867'] - [autonomic_autoantibody_assay, evidence_for, pots, 'pmid40537187; pmid40432440; pmid39202605; pmid38673062; pmid37654428; pmid34471867; pmid34409582; pmid34275953; pmid34117922; pmid33562074; pmid32743496; pmid31495251; pmid31139694; pmid29687025; pmid29618472; pmid27702852; pmid24572257; pmid23002038'] - [cardiac_mri, evidence_for, deconditioning_evidence, 'pmid20579544'] - [cardiac_mri, evidence_for, pots, 'pmid20579544'] - [cardiopulmonary_exercise_test, evidence_for, deconditioning_evidence, 'pmid24819031; pmid23729158'] - [cardiopulmonary_exercise_test, evidence_for, hyperadrenergic_evidence, 'pmid40313612'] - [cardiopulmonary_exercise_test, evidence_for, pots, 'pmid41357159; pmid40313612; pmid27884959; pmid25168872'] - [cerebral_blood_flow_measurement, evidence_for, cerebral_hypoperfusion_evidence, 'pmid39895557; pmid37227184; pmid35056406; pmid32545797; pmid32140630; pmid30256820; pmid24711524; pmid33947430; pmid33352894; pmid33280488; pmid33050553; pmid25002851; pmid16627440'] - [cerebral_blood_flow_measurement, evidence_for, differential_syncope_oh, 'pmid27525257'] - [cerebral_blood_flow_measurement, evidence_for, long_covid, 'pmid39895557'] - [cerebral_blood_flow_measurement, evidence_for, me_cfs, 'pmid32140630'] - [cerebral_blood_flow_measurement, evidence_for, pots, 'pmid39895557; pmid27525257; pmid39875497; pmid39297140; pmid37227184; pmid35673757; pmid33352894; pmid33280488; pmid30256820; pmid25510829; pmid25002851; pmid24711524'] - [end_tidal_co2, evidence_for, cerebral_hypoperfusion_evidence, 'pmid30256820'] - [end_tidal_co2, evidence_for, pots, 'pmid35891154; pmid33352894'] - [genetic_testing, evidence_for, autoimmune_evidence, 'pmid31139694'] - [genetic_testing, evidence_for, pots, 'pmid39964606; pmid16203873'] - [head_up_tilt_test, evidence_for, cerebral_hypoperfusion_evidence, 'pmid41357159; pmid39544990; pmid35056406; pmid32140630; pmid24711524; pmid39895557; pmid33947430; pmid33352894; pmid16627440'] - [head_up_tilt_test, evidence_for, differential_syncope_oh, 'pmid33150760; pmid27525257; pmid35372154; pmid35097001; pmid33886735; pmid33582941; pmid31250563; pmid28720881; pmid28674628; pmid28554964; pmid28286774; pmid27702852; pmid21977261; pmid17205918; pmid16627440; pmid11975909'] - [head_up_tilt_test, evidence_for, hyperadrenergic_evidence, 'pmid41300849; pmid38168762; pmid33927679; pmid33886001; pmid32880754; pmid29326369; pmid19207771; pmid36000360; pmid33860871; pmid25033770; pmid21977261'] - [head_up_tilt_test, evidence_for, long_covid, 'pmid36614874; pmid35381331; pmid42343084; pmid39895557'] - [head_up_tilt_test, evidence_for, mast_cell_activation, 'pmid39165715'] - [head_up_tilt_test, evidence_for, neuropathic_evidence, 'pmid34674068; pmid8988490'] - [head_up_tilt_test, evidence_for, postinfectious_evidence, 'pmid35381331'] - [head_up_tilt_test, evidence_for, pots, 'pmid42458878; pmid42342403; pmid42273028; pmid41446482; pmid41420770; pmid41300849; pmid41156242; pmid40959677; pmid40761644; pmid40585261; pmid40533427; pmid40437589; pmid40433210; pmid40432440; pmid40271232; pmid40003288; pmid39552985; pmid39308845; pmid39165715; pmid39109119; pmid38962840; pmid38585346; pmid38486257; pmid38348221; pmid38168762; pmid38033543; pmid37508741; pmid37443510; pmid37378800; pmid36518687; pmid36397456; pmid36339677; pmid36111700; pmid36090156; pmid35844239; pmid35742222; pmid35620060; pmid35463901; pmid35433537; pmid35381331; pmid35372154; pmid35288409; pmid34993394; pmid34821709; pmid34604136; pmid34471867; pmid34275953; pmid33927679; pmid33886735; pmid33886001; pmid33860871; pmid33723532; pmid33582941; pmid33505857; pmid33490373; pmid33352894; pmid33262898; pmid33178533; pmid32222376; pmid32112609; pmid31888497; pmid31780890; pmid30560108; pmid30505831; pmid30372565; pmid30305583; pmid29451148; pmid29391028; pmid29326369; pmid28674628; pmid28554964; pmid28286774; pmid27702852; pmid27631244; pmid27413567; pmid26645307; pmid26198889; pmid25917768; pmid25811760; pmid25510829; pmid25180969; pmid25002851; pmid24819031; pmid24711524; pmid23862007; pmid23802020; pmid23729158; pmid23390443; pmid23270259; pmid22889291; pmid22689545; pmid21977261; pmid20309394; pmid20167544; pmid19264762; pmid19207771; pmid11227722; pmid10406593; pmid40584422; pmid39895557; pmid39664665; pmid37519618; pmid36873318; pmid36475233; pmid35725868; pmid35680184; pmid35557616; pmid35097001; pmid35056406; pmid33423527; pmid33114659; pmid32880754; pmid32848537; pmid32669178; pmid32078525; pmid30879357; pmid30755882; pmid30197684; pmid25748400; pmid25071706; pmid24601948; pmid22739942; pmid16176538; pmid8423877'] - [heart_rate_variability, evidence_for, hyperadrenergic_evidence, 'pmid21977261'] - [heart_rate_variability, evidence_for, hypermobility_heds, 'pmid28286774'] - [heart_rate_variability, evidence_for, long_covid, 'pmid42343084; pmid36298551; pmid33935300'] - [heart_rate_variability, evidence_for, neuropathic_evidence, 'pmid30879357; pmid41767063'] - [heart_rate_variability, evidence_for, postinfectious_evidence, 'pmid33935300'] - [heart_rate_variability, evidence_for, pots, 'pmid41300849; pmid35118574; pmid33935300; pmid33423527; pmid32848537; pmid31780890; pmid30879357; pmid22247480; pmid21977261; pmid10406593'] - [muscle_sympathetic_nerve_activity, evidence_for, hyperadrenergic_evidence, 'pmid41533304; pmid39109428; pmid26198889; pmid20035362; pmid40951270; pmid15533861'] - [muscle_sympathetic_nerve_activity, evidence_for, neuropathic_evidence, 'pmid30879357'] - [muscle_sympathetic_nerve_activity, evidence_for, pots, 'pmid41533304; pmid40951270; pmid40350041; pmid39109428; pmid38176772; pmid30879357; pmid26198889; pmid22934032; pmid20035362'] - [plasma_blood_volume_assay, evidence_for, deconditioning_evidence, 'pmid20579544'] - [plasma_blood_volume_assay, evidence_for, hypovolemic_evidence, 'pmid39614968; pmid33926653; pmid23753844; pmid20579544'] - [plasma_blood_volume_assay, evidence_for, pots, 'pmid39614968; pmid37393658; pmid33926653; pmid23753844; pmid20579544'] - [plasma_catecholamine_assay, evidence_for, hyperadrenergic_evidence, 'pmid40537187; pmid37261636; pmid34471549; pmid33926653; pmid33886735; pmid33150760; pmid27625098; pmid23753844; pmid22783324; pmid16943900; pmid41533304; pmid35992935; pmid25120493; pmid21266211'] - [plasma_catecholamine_assay, evidence_for, neuropathic_evidence, 'pmid35992935'] - [plasma_catecholamine_assay, evidence_for, pots, 'pmid22783324; pmid37261636; pmid34471549; pmid26198889; pmid21266211'] - [qsart_sudomotor_testing, evidence_for, hyperadrenergic_evidence, 'pmid25180969; pmid33860871'] - [qsart_sudomotor_testing, evidence_for, long_covid, 'pmid41275041; pmid36718227'] - [qsart_sudomotor_testing, evidence_for, neuropathic_evidence, 'pmid41275041; pmid40608783; pmid36349067; pmid35181863; pmid26198889; pmid25120493; pmid25033770; pmid24819031; pmid24386408; pmid19207771; pmid16943900; pmid37435242; pmid34144933; pmid21906029'] - [qsart_sudomotor_testing, evidence_for, pots, 'pmid35181863; pmid25180969; pmid20035362'] - [qsart_sudomotor_testing, evidence_for, small_fiber_neuropathy_dx, 'pmid42273028; pmid36349067'] - [quantitative_sensory_testing, evidence_for, neuropathic_evidence, 'pmid24386408'] - [quantitative_sensory_testing, evidence_for, small_fiber_neuropathy_dx, 'pmid33299671'] - [regional_norepinephrine_spillover, evidence_for, neuropathic_evidence, 'pmid36349067; pmid25053240; pmid19207771; pmid16943900; pmid20035362'] - [regional_norepinephrine_spillover, evidence_for, pots, 'pmid25120493'] - [skin_biopsy_ienfd, evidence_for, neuropathic_evidence, 'pmid42273028; pmid38390594; pmid36349067; pmid34471867; pmid33764697; pmid25053240; pmid24386408'] - [skin_biopsy_ienfd, evidence_for, pots, 'pmid25053240'] - [skin_biopsy_ienfd, evidence_for, small_fiber_neuropathy_dx, 'pmid42273028; pmid36349067; pmid36090156; pmid34471867; pmid33764697'] - [thermoregulatory_sweat_test, evidence_for, neuropathic_evidence, 'pmid33860871; pmid26198889; pmid25033770; pmid29102451'] - [thermoregulatory_sweat_test, evidence_for, small_fiber_neuropathy_dx, 'pmid33860871'] - [urine_sodium_24h, evidence_for, hypovolemic_evidence, 'pmid37508589; pmid32655482; pmid27625098'] - [urine_sodium_24h, evidence_for, pots, 'pmid37705599; pmid32655482; pmid27625098'] - [valsalva_maneuver, evidence_for, hyperadrenergic_evidence, 'pmid41533304; pmid40951270; pmid39109428; pmid38937334; pmid33886735; pmid33886001; pmid32880754'] - [valsalva_maneuver, evidence_for, neuropathic_evidence, 'pmid36349067; pmid30879357; pmid25033770; pmid8988490'] - [valsalva_maneuver, evidence_for, pots, 'pmid41533304; pmid40951270; pmid33486983; pmid30879357; pmid25071706; pmid23729158'] # indicates - [antihistamine_therapy, indicates, mast_cell_activation, 'pmid40627388; pmid38526146; pmid38003876; pmid34398691'] - [auricular_vagus_nerve_stimulation, indicates, long_covid, 'pmid40014480'] - [beta_blocker_therapy, indicates, chronic_migraine, 'pmid33174112'] - [beta_blocker_therapy, indicates, hyperadrenergic_evidence, 'pmid41767063; pmid40626134; pmid40537187; pmid39768649; pmid39706392; pmid39202605; pmid38937334; pmid38168762; pmid38033543; pmid37508589; pmid36781629; pmid36187012; pmid36158335; pmid35742222; pmid35127870; pmid33178533; pmid32974246; pmid32655482; pmid32494413; pmid31412221; pmid25811760; pmid24982638; pmid22783324; pmid21802629; pmid42132710; pmid34035985; pmid26198889; pmid25204388'] - [central_sympatholytic_therapy, indicates, hyperadrenergic_evidence, 'pmid42696970; pmid41533304; pmid40951270; pmid39109428; pmid36074973; pmid29102451; pmid25980576; pmid23753844; pmid23217691; pmid16943900'] - [compression_therapy, indicates, hyperadrenergic_evidence, 'pmid38260095'] - [compression_therapy, indicates, hypermobility_heds, 'pmid36694653'] - [compression_therapy, indicates, hypovolemic_evidence, 'pmid38328599'] - [compression_therapy, indicates, long_covid, 'pmid37654428'] - [compression_therapy, indicates, neuropathic_evidence, 'pmid31412221'] - [exercise_reconditioning, indicates, arrhythmia_differential, 'pmid36074973'] - [exercise_reconditioning, indicates, cerebral_hypoperfusion_evidence, 'pmid39540412'] - [exercise_reconditioning, indicates, deconditioning_evidence, 'pmid39597891; pmid30001836; pmid25487551; pmid24819031; pmid20579544; pmid39678714; pmid37598401; pmid33423527; pmid28286774; pmid21690484; pmid19207771'] - [exercise_reconditioning, indicates, hypovolemic_evidence, 'pmid31412221; pmid20579544'] - [exercise_reconditioning, indicates, long_covid, 'pmid37654428; pmid39202605; pmid39198662'] - [exercise_reconditioning, indicates, neuropathic_evidence, 'pmid34674068'] - [exercise_reconditioning, indicates, secondary_sinus_tachycardia, 'pmid36074973'] - [immunomodulatory_therapy, indicates, autoimmune_evidence, 'pmid41089328; pmid38311655; pmid35557616; pmid34471867; pmid34117922; pmid32750291; pmid29781817; pmid40624434; pmid38673062; pmid36008726; pmid33505857; pmid31139694; pmid27702852'] - [immunomodulatory_therapy, indicates, long_covid, 'pmid41089328; pmid42605371; pmid34993394'] - [immunomodulatory_therapy, indicates, mast_cell_activation, 'pmid38003876; pmid29326369'] - [immunomodulatory_therapy, indicates, neuropathic_evidence, 'pmid34471867'] - [immunomodulatory_therapy, indicates, systemic_autoimmune_disease, 'pmid41089328'] - [ivabradine_therapy, indicates, hyperadrenergic_evidence, 'pmid38168762; pmid40537187'] - [ivabradine_therapy, indicates, long_covid, 'pmid37469536; pmid35853576'] - [lifestyle_modification, indicates, gi_dysmotility, 'pmid42509985'] - [lifestyle_modification, indicates, hypovolemic_evidence, 'pmid41301791; pmid37393658; pmid33689063; pmid32974246; pmid32494413; pmid22783324'] - [lifestyle_modification, indicates, long_covid, 'pmid37654428'] - [lifestyle_modification, indicates, postinfectious_evidence, 'pmid37654428'] - [midodrine_therapy, indicates, neuropathic_evidence, 'pmid42037960; pmid41446482; pmid37508589; pmid32655482; pmid23978222; pmid23217691'] - [prokinetic_therapy, indicates, gi_dysmotility, 'pmid42509985; pmid24819031'] - [pyridostigmine_therapy, indicates, autoimmune_evidence, 'pmid32655482'] - [serotonergic_therapy, indicates, anxiety_depression, 'pmid40454385'] - [volume_expansion_therapy, indicates, hypovolemic_evidence, 'pmid42037960; pmid40601666; pmid38328599; pmid38168762; pmid37393658; pmid36518330; pmid34327047; pmid33926653; pmid32974246; pmid25980576; pmid23217691; pmid22783324; pmid22561596; pmid20668563; pmid16943900; pmid9244228; pmid35742222; pmid34928881; pmid33689063; pmid33178533; pmid32494413; pmid30001836; pmid28185102'] # treats - [antihistamine_therapy, treats, mast_cell_activation, 'pmid40627388; pmid38003876; pmid38867988'] - [auricular_vagus_nerve_stimulation, treats, long_covid, 'pmid40014480'] - [auricular_vagus_nerve_stimulation, treats, pots, 'pmid42342403; pmid40014480; pmid38173801; pmid37999672; pmid37705568; pmid37631004'] - [beta_blocker_therapy, treats, pots, 'pmid42605371; pmid42591853; pmid42299168; pmid42132710; pmid41827215; pmid41767063; pmid41446482; pmid41357159; pmid41225175; pmid40681233; pmid40627388; pmid40626134; pmid40601666; pmid40520610; pmid40437589; pmid39882369; pmid39852767; pmid39559520; pmid39552985; pmid39538129; pmid39202605; pmid38240001; pmid38033543; pmid37654428; pmid37519618; pmid37508589; pmid37443510; pmid37313107; pmid37204997; pmid37009342; pmid36938206; pmid36781629; pmid36518330; pmid36187012; pmid35742222; pmid35288409; pmid35176758; pmid35127870; pmid34928881; pmid34847948; pmid34390682; pmid34387611; pmid34353826; pmid34327047; pmid34144933; pmid34035985; pmid33623665; pmid32974246; pmid32673517; pmid32655482; pmid32494413; pmid32489723; pmid32464225; pmid32112609; pmid31802934; pmid31788462; pmid31780890; pmid29343965; pmid29102451; pmid27625098; pmid26241226; pmid26199795; pmid26198889; pmid25980576; pmid25811760; pmid25204388; pmid23753844; pmid23616163; pmid23217691; pmid21977261; pmid21802629; pmid21690484; pmid21686452; pmid20860911; pmid20668563; pmid19687359; pmid11206727; pmid11201632; pmid11198485; pmid10750641; pmid10406593; pmid40624434; pmid40537187; pmid38867988; pmid36158335; pmid33723532; pmid19207771; pmid17933281'] - [central_sympatholytic_therapy, treats, pots, 'pmid40681233; pmid39559520; pmid39202605; pmid39109428; pmid36074973; pmid33886735; pmid32805514; pmid25980576; pmid23753844; pmid23217691; pmid16943900; pmid42696970; pmid41446482; pmid40951270; pmid29102451; pmid21802629; pmid19207771'] - [compression_therapy, treats, pots, 'pmid42299168; pmid41976810; pmid41898333; pmid41483109; pmid41338488; pmid41225175; pmid40627388; pmid40475217; pmid39685762; pmid39614865; pmid39582711; pmid39538129; pmid39202605; pmid38260095; pmid37248893; pmid37009342; pmid36694653; pmid36074973; pmid34390682; pmid33478652; pmid32673517; pmid32494413; pmid31788462; pmid30001836; pmid29343965; pmid26198889; pmid24840763; pmid23753844; pmid16943900; pmid21802629'] - [droxidopa_therapy, treats, pots, 'pmid39538129'] - [exercise_reconditioning, treats, long_covid, 'pmid37654428; pmid39198662'] - [exercise_reconditioning, treats, pots, 'pmid42299168; pmid41225175; pmid41166031; pmid40944681; pmid40538940; pmid40365455; pmid40125494; pmid39822199; pmid39678714; pmid39597891; pmid39559520; pmid39540412; pmid39538129; pmid39202605; pmid38958137; pmid38953100; pmid38162438; pmid37598401; pmid37519618; pmid37435242; pmid37204997; pmid37009342; pmid36339677; pmid35697326; pmid34928881; pmid34144933; pmid33886735; pmid33482385; pmid33423527; pmid33083000; pmid32655482; pmid32489723; pmid32284866; pmid31802934; pmid30001836; pmid29864098; pmid27625098; pmid26198889; pmid25487551; pmid24982638; pmid24819031; pmid23753844; pmid23217691; pmid22783324; pmid21690484; pmid20579544; pmid20309394; pmid18704621; pmid38937334; pmid38074226; pmid36852364; pmid36090156; pmid34327047; pmid33860871; pmid33178533; pmid32494413; pmid28286774; pmid19207771'] - [immunomodulatory_therapy, treats, long_covid, 'pmid41089328'] - [immunomodulatory_therapy, treats, mast_cell_activation, 'pmid29326369; pmid38003876'] - [immunomodulatory_therapy, treats, pots, 'pmid41089328; pmid39559520; pmid39538129; pmid38673062; pmid36008726; pmid35557616; pmid34471867; pmid34117922; pmid33677650; pmid33382525; pmid29326369; pmid41403551; pmid40624434; pmid34993394; pmid33505857; pmid32750291; pmid31547756'] - [immunomodulatory_therapy, treats, small_fiber_neuropathy_dx, 'pmid41403551'] - [immunomodulatory_therapy, treats, systemic_autoimmune_disease, 'pmid41089328'] - [ivabradine_therapy, treats, long_covid, 'pmid35853576'] - [ivabradine_therapy, treats, pots, 'pmid42605371; pmid42484150; pmid42273028; pmid42132710; pmid41538594; pmid41446482; pmid41364925; pmid41357159; pmid41225175; pmid40692561; pmid40681233; pmid40627388; pmid40624434; pmid40537187; pmid40294227; pmid39882369; pmid39559520; pmid39538129; pmid39355826; pmid39202605; pmid39109119; pmid38168762; pmid37654428; pmid37313107; pmid37204997; pmid37009342; pmid36852364; pmid36575713; pmid36074973; pmid35891154; pmid35853576; pmid34928881; pmid34390682; pmid34327047; pmid34127505; pmid34035985; pmid33723532; pmid33602468; pmid33262898; pmid32489723; pmid29343965; pmid29330767; pmid29102451; pmid29027608; pmid28846151; pmid28496661; pmid27413567; pmid26241226; pmid25980576; pmid24072450; pmid22783324; pmid42591853; pmid34144933; pmid29876157'] - [lifestyle_modification, treats, long_covid, 'pmid37654428'] - [lifestyle_modification, treats, pots, 'pmid35697326; pmid42299168; pmid41301791; pmid41142154; pmid40869705; pmid40624434; pmid39559520; pmid39552985; pmid39355826; pmid39202605; pmid39109119; pmid38962840; pmid38958137; pmid38074226; pmid37654428; pmid37519618; pmid37248893; pmid37204997; pmid36938206; pmid36339677; pmid36074973; pmid34928881; pmid34792683; pmid34786979; pmid33689063; pmid33490373; pmid33262898; pmid32494413; pmid29628432; pmid29549458; pmid29343965; pmid28674681; pmid23999934; pmid23753844; pmid22783324; pmid21977261; pmid16943900'] - [midodrine_therapy, treats, pots, 'pmid42299168; pmid42037960; pmid41446482; pmid41225175; pmid39202605; pmid38168762; pmid37706146; pmid37654428; pmid37508589; pmid37313107; pmid37248893; pmid36339677; pmid35742222; pmid35557616; pmid35288409; pmid34733680; pmid34471867; pmid34327047; pmid34144933; pmid32655482; pmid32494413; pmid31802934; pmid29343965; pmid29102451; pmid27625098; pmid26610893; pmid26241226; pmid26198889; pmid25980576; pmid24982638; pmid24857518; pmid24253613; pmid23978222; pmid23753844; pmid23244360; pmid23217691; pmid21301135; pmid20668563; pmid16943900; pmid10750641; pmid40626134; pmid38937334; pmid34035985; pmid32295399; pmid21802629; pmid20309394'] - [offending_medication_withdrawal, treats, pots, 'pmid42037960; pmid39109119; pmid37248893; pmid34327047; pmid26241226; pmid23217691'] - [phenobarbital_therapy, treats, pots, 'pmid19207771'] - [physical_countermaneuvers, treats, pots, 'pmid41976810; pmid39538129; pmid36074973; pmid35742222; pmid34729276; pmid33723532; pmid33178533; pmid30001836; pmid29343965; pmid26199795; pmid19207771; pmid39559520'] - [prokinetic_therapy, treats, gi_dysmotility, 'pmid42509985; pmid24819031'] - [pyridostigmine_therapy, treats, pots, 'pmid41684377; pmid41225175; pmid40681233; pmid39852767; pmid39202605; pmid37313107; pmid37204997; pmid37009342; pmid36074973; pmid35288409; pmid34327047; pmid33886735; pmid33423527; pmid33244220; pmid32655482; pmid31788462; pmid29102451; pmid26198889; pmid25980576; pmid24982638; pmid24819031; pmid23244360; pmid23217691; pmid22783324; pmid21410722; pmid16943900; pmid15911704'] - [serotonergic_therapy, treats, anxiety_depression, 'pmid40454385'] - [serotonergic_therapy, treats, pots, 'pmid24227635; pmid20309394; pmid40454385; pmid39559520; pmid35870963; pmid34928881; pmid24819031; pmid21802629'] - [volume_expansion_therapy, treats, pots, 'pmid42299168; pmid42037960; pmid40601666; pmid39852767; pmid39559520; pmid39538129; pmid38958137; pmid37435242; pmid37248893; pmid37204997; pmid36938206; pmid36718484; pmid35697326; pmid35288409; pmid33926653; pmid33723532; pmid32974246; pmid32655482; pmid32494413; pmid30076469; pmid30001836; pmid29102451; pmid26198889; pmid23999934; pmid23217691; pmid22783324; pmid22561596; pmid21802629; pmid16943900; pmid40761644; pmid38240001; pmid36074973; pmid35870963; pmid35742222; pmid34928881; pmid34327047; pmid33262898; pmid33178533; pmid31405524; pmid25980576; pmid24982638; pmid23753844; pmid20309394'] # associated_with - [anxiety_depression, associated_with, cerebral_hypoperfusion_evidence, 'pmid30883381'] - [anxiety_depression, associated_with, endometriosis, 'pmid42787977'] - [anxiety_depression, associated_with, functional_neurological_disorder, 'pmid38953100'] - [anxiety_depression, associated_with, gi_dysmotility, 'pmid39543811; pmid41952073'] - [anxiety_depression, associated_with, hyperadrenergic_evidence, 'pmid23580201; pmid40276022'] - [anxiety_depression, associated_with, hypermobility_heds, 'pmid41446482; pmid32295399'] - [anxiety_depression, associated_with, long_covid, 'pmid38510743; pmid34821709; pmid39317338; pmid38240001'] - [anxiety_depression, associated_with, mast_cell_activation, 'pmid38003876'] - [anxiety_depression, associated_with, postinfectious_evidence, 'pmid38510743; pmid34821709'] - [anxiety_depression, associated_with, pots, 'pmid42787977; pmid41952073; pmid41740821; pmid40454385; pmid40003288; pmid39838139; pmid39308845; pmid38240001; pmid37338634; pmid33114659; pmid31802934; pmid29628432; pmid25852449; pmid25713509; pmid25009504; pmid23580201; pmid42342500; pmid40276022; pmid39884840; pmid39540412; pmid38003876; pmid34928881; pmid34866935; pmid34746821; pmid32993834; pmid32974246; pmid32655482; pmid28442939; pmid25001527; pmid24819031; pmid22156614; pmid18977825'] - [anxiety_depression, associated_with, sleep_disturbance, 'pmid40648966; pmid28442939'] - [arrhythmia_differential, associated_with, long_covid, 'pmid40692561; pmid35355961'] - [arrhythmia_differential, associated_with, pots, 'pmid33654569; pmid34035985'] - [autoimmune_evidence, associated_with, gi_dysmotility, 'pmid34993884; pmid33621398'] - [autoimmune_evidence, associated_with, hyperadrenergic_evidence, 'pmid40537187; pmid33886735; pmid29682372'] - [autoimmune_evidence, associated_with, long_covid, 'pmid41859298; pmid41089328; pmid38673062; pmid37255928; pmid34821709; pmid39200375; pmid38900132; pmid38173801; pmid38173173; pmid37009342; pmid36509178'] - [autoimmune_evidence, associated_with, mast_cell_activation, 'pmid35062788; pmid33886735'] - [autoimmune_evidence, associated_with, neuropathic_evidence, 'pmid38537312; pmid41089328; pmid36349067; pmid28116654'] - [autoimmune_evidence, associated_with, post_vaccination_onset, 'pmid38673062; pmid38173801; pmid36475233; pmid35870086'] - [autoimmune_evidence, associated_with, postinfectious_evidence, 'pmid38673062; pmid37009342; pmid25087056; pmid41089328; pmid39200375; pmid38173801; pmid38173173; pmid34144933; pmid29687025; pmid28738696; pmid26198889; pmid19058765'] - [autoimmune_evidence, associated_with, pots, 'pmid41952073; pmid41446482; pmid41089328; pmid40537187; pmid39527936; pmid39200375; pmid38900132; pmid38673062; pmid38348221; pmid38311655; pmid38173801; pmid38173173; pmid37255928; pmid36816268; pmid36639608; pmid35269395; pmid34144933; pmid34055446; pmid33621398; pmid33562074; pmid32983103; pmid32974246; pmid32750291; pmid32743496; pmid31547749; pmid31495251; pmid31139694; pmid31001074; pmid29909990; pmid29864098; pmid29687025; pmid29618472; pmid28738696; pmid27702852; pmid26038344; pmid25087056; pmid23002038; pmid41859298; pmid41146789; pmid40432440; pmid39559520; pmid37009342; pmid36908200; pmid36611357; pmid36509178; pmid36475233; pmid36074973; pmid35870086; pmid35062788; pmid34993884; pmid34895744; pmid34866935; pmid34484936; pmid34471867; pmid33886735; pmid31547756; pmid29682372; pmid26198889; pmid19058765'] - [autoimmune_evidence, associated_with, small_fiber_neuropathy_dx, 'pmid38537312'] - [autoimmune_evidence, associated_with, systemic_autoimmune_disease, 'pmid41952073; pmid41446482; pmid41089328; pmid38673062; pmid36816268; pmid36349067; pmid36074973; pmid35156619; pmid34144933; pmid34055446; pmid31498378; pmid29864098'] - [cerebral_hypoperfusion_evidence, associated_with, fibromyalgia, 'pmid41602336'] - [cerebral_hypoperfusion_evidence, associated_with, hormonal_transition_onset, 'pmid31798399'] - [cerebral_hypoperfusion_evidence, associated_with, hypermobility_heds, 'pmid39875497'] - [cerebral_hypoperfusion_evidence, associated_with, hypovolemic_evidence, 'pmid41602336'] - [cerebral_hypoperfusion_evidence, associated_with, long_covid, 'pmid40014480; pmid39875497'] - [cerebral_hypoperfusion_evidence, associated_with, me_cfs, 'pmid32140630'] - [cerebral_hypoperfusion_evidence, associated_with, pots, 'pmid41602336; pmid39544990; pmid35891154; pmid32140630; pmid30256820; pmid24711524; pmid42605371; pmid41952073; pmid41740821; pmid41300849; pmid41020219; pmid39875497; pmid35689118; pmid35463901; pmid33777484; pmid33280488; pmid33050553; pmid25002851; pmid22156614'] - [chronic_migraine, associated_with, fibromyalgia, 'pmid23862007'] - [chronic_migraine, associated_with, hyperadrenergic_evidence, 'pmid38912309'] - [chronic_migraine, associated_with, mast_cell_activation, 'pmid38003876'] - [chronic_migraine, associated_with, pots, 'pmid41420770; pmid40585261; pmid40520610; pmid39559520; pmid38966085; pmid38912309; pmid36992793; pmid36590760; pmid35288409; pmid34866935; pmid34246578; pmid34144933; pmid33174112; pmid32823577; pmid31802934; pmid31549738; pmid26198889; pmid24819031; pmid20819844; pmid23862007'] - [chronic_migraine, associated_with, systemic_autoimmune_disease, 'pmid42299385'] - [deconditioning_evidence, associated_with, fibromyalgia, 'pmid23862007'] - [deconditioning_evidence, associated_with, gi_dysmotility, 'pmid25483980'] - [deconditioning_evidence, associated_with, hyperadrenergic_evidence, 'pmid33860871'] - [deconditioning_evidence, associated_with, hypermobility_heds, 'pmid34331416'] - [deconditioning_evidence, associated_with, long_covid, 'pmid34265539'] - [deconditioning_evidence, associated_with, pots, 'pmid41357159; pmid40538940; pmid36000435; pmid35557616; pmid31802934; pmid29523389; pmid26198889; pmid25980576; pmid25168872; pmid24819031; pmid24386408; pmid34265539; pmid33860871; pmid28286774; pmid25483980'] - [deconditioning_evidence, associated_with, prolonged_bed_rest, 'pmid34265539; pmid29523389'] - [differential_syncope_oh, associated_with, me_cfs, 'pmid35056406'] - [differential_syncope_oh, associated_with, pots, 'pmid41300849; pmid36518687; pmid36252987; pmid33490373; pmid31250563; pmid30838497; pmid26198889'] - [endometriosis, associated_with, mast_cell_activation, 'pmid37241210'] - [endometriosis, associated_with, pots, 'pmid42787977; pmid42641290; pmid37234076; pmid22721633'] - [fibromyalgia, associated_with, gi_dysmotility, 'pmid39543811'] - [fibromyalgia, associated_with, hypermobility_heds, 'pmid25917768; pmid42691689; pmid39582682'] - [fibromyalgia, associated_with, me_cfs, 'pmid40890788'] - [fibromyalgia, associated_with, pots, 'pmid42691689; pmid40546538; pmid38348221; pmid29876157; pmid26425598; pmid23862007'] - [functional_neurological_disorder, associated_with, pots, 'pmid38953100; pmid42804409; pmid37378164'] - [gi_dysmotility, associated_with, hypermobility_heds, 'pmid42509985; pmid41858767; pmid39543811; pmid34765384; pmid32803794; pmid32489735; pmid29891041; pmid29549458; pmid42691689; pmid40387691; pmid39268060'] - [gi_dysmotility, associated_with, hypovolemic_evidence, 'pmid25483980'] - [gi_dysmotility, associated_with, mast_cell_activation, 'pmid40856938; pmid29326369'] - [gi_dysmotility, associated_with, neuropathic_evidence, 'pmid42153984; pmid29549458; pmid23708963; pmid41858767'] - [gi_dysmotility, associated_with, pots, 'pmid42691689; pmid42509985; pmid42156945; pmid42153984; pmid41952405; pmid41952073; pmid41858767; pmid40856938; pmid40608783; pmid39268060; pmid38348221; pmid35307584; pmid34765384; pmid34144933; pmid33621398; pmid33428036; pmid32494413; pmid32489735; pmid30072778; pmid29343965; pmid29326369; pmid28191707; pmid26671111; pmid25483980; pmid24819031; pmid19424509; pmid42437376; pmid39543811; pmid34993884; pmid33150760; pmid32803794; pmid29549458; pmid24068608; pmid23708963; pmid23212662'] - [hormonal_transition_onset, associated_with, hypovolemic_evidence, 'pmid31798399'] - [hormonal_transition_onset, associated_with, pots, 'pmid41753164; pmid36908200; pmid31798399'] - [hyperadrenergic_evidence, associated_with, hypermobility_heds, 'pmid41924132; pmid39301475; pmid35620060; pmid34510391; pmid25713509'] - [hyperadrenergic_evidence, associated_with, hypovolemic_evidence, 'pmid40601666'] - [hyperadrenergic_evidence, associated_with, long_covid, 'pmid39301475; pmid40014480; pmid39076856; pmid38173173'] - [hyperadrenergic_evidence, associated_with, mast_cell_activation, 'pmid39109428; pmid38526146; pmid37255928; pmid34928881; pmid29523389; pmid26198889; pmid23753844; pmid16943900; pmid15710782; pmid29326369'] - [hyperadrenergic_evidence, associated_with, postinfectious_evidence, 'pmid38173173'] - [hyperadrenergic_evidence, associated_with, pots, 'pmid39559520; pmid38168762; pmid37508741; pmid37508589; pmid35232225; pmid32621993; pmid32494413; pmid31788462; pmid29523389; pmid25120493; pmid24711524; pmid23753844; pmid23538032; pmid21266211; pmid16943900; pmid42254140; pmid41924132; pmid41533304; pmid41300853; pmid40537187; pmid40276022; pmid39768649; pmid39301475; pmid39109428; pmid38673062; pmid38173173; pmid37705599; pmid37654428; pmid37378164; pmid37255928; pmid37009342; pmid35818599; pmid35620060; pmid35351159; pmid34928881; pmid33860871; pmid33654569; pmid33371330; pmid33178533; pmid32974246; pmid30076469; pmid29682372; pmid27558116; pmid26198889; pmid21906029; pmid21802629; pmid15710782; pmid11206727'] - [hyperadrenergic_evidence, associated_with, sleep_disturbance, 'pmid42254140; pmid35303039; pmid25474569; pmid23538032'] - [hypermobility_heds, associated_with, long_covid, 'pmid41282714; pmid40624434'] - [hypermobility_heds, associated_with, mast_cell_activation, 'pmid41282714; pmid40843452; pmid40352770; pmid39931100; pmid38003876; pmid35288409'] - [hypermobility_heds, associated_with, me_cfs, 'pmid41282714; pmid40978926; pmid24934205'] - [hypermobility_heds, associated_with, neurodevelopmental_disorder, 'pmid41686757'] - [hypermobility_heds, associated_with, neuropathic_evidence, 'pmid40843452; pmid34055418'] - [hypermobility_heds, associated_with, physical_trauma_onset, 'pmid29864098'] - [hypermobility_heds, associated_with, post_vaccination_onset, 'pmid40729147'] - [hypermobility_heds, associated_with, postinfectious_evidence, 'pmid41282714'] - [hypermobility_heds, associated_with, pots, 'pmid42691689; pmid42509985; pmid42037722; pmid41952073; pmid41924132; pmid41898333; pmid41858767; pmid41801611; pmid41446482; pmid41301791; pmid41282714; pmid41156242; pmid41020219; pmid40729147; pmid40624434; pmid40546538; pmid40530951; pmid40520610; pmid40387691; pmid40352770; pmid39875497; pmid39850941; pmid39582682; pmid39559520; pmid39301475; pmid39268060; pmid38958137; pmid38912309; pmid38673548; pmid38545281; pmid38469013; pmid38348221; pmid38275067; pmid38162438; pmid37234076; pmid36908200; pmid36694653; pmid36590760; pmid36437696; pmid36000435; pmid35620060; pmid35557616; pmid35525992; pmid35288409; pmid35224842; pmid34866935; pmid34765384; pmid34510391; pmid34246578; pmid34144933; pmid34055418; pmid33886735; pmid33388686; pmid33244220; pmid32803794; pmid31954224; pmid29876157; pmid29864098; pmid29549458; pmid29523389; pmid29519641; pmid29343965; pmid28286774; pmid27660311; pmid26198889; pmid25852449; pmid25713509; pmid25156902; pmid24819031; pmid22889291; pmid22143364; pmid42804409; pmid39308845; pmid38985772; pmid38003876; pmid35673757; pmid35269395; pmid34766441; pmid33677650; pmid33562074; pmid32489735; pmid32295399; pmid31802934; pmid30755882; pmid30001836; pmid29891041; pmid28986003; pmid28924124; pmid24934205; pmid22739942; pmid20376184; pmid19946638'] - [hypovolemic_evidence, associated_with, long_covid, 'pmid38240001; pmid37435242'] - [hypovolemic_evidence, associated_with, neuropathic_evidence, 'pmid33490373'] - [hypovolemic_evidence, associated_with, pots, 'pmid40601666; pmid37435242; pmid32655482; pmid23753844; pmid16262605; pmid40027266; pmid34268642; pmid33490373; pmid25483980'] - [iron_deficiency, associated_with, pots, 'pmid32974246; pmid23720007; pmid39559520; pmid21886073'] - [long_covid, associated_with, mast_cell_activation, 'pmid37255928; pmid36981522; pmid34821709; pmid33869099'] - [long_covid, associated_with, me_cfs, 'pmid41859298; pmid40627388; pmid38600563; pmid36981522; pmid36639608; pmid36611357; pmid33996867; pmid41050528; pmid40883051; pmid35241011'] - [long_covid, associated_with, neuropathic_evidence, 'pmid39852767; pmid37009342; pmid36938206; pmid36718484; pmid36639608'] - [long_covid, associated_with, postinfectious_evidence, 'pmid41859298; pmid37435242; pmid37391116; pmid37255928; pmid37009342; pmid35381331; pmid35241011; pmid34993394; pmid34607799; pmid33927679; pmid33786700; pmid42512077; pmid42279051; pmid41713697; pmid41282714; pmid41146789; pmid41089328; pmid41050528; pmid41038948; pmid41020219; pmid40883051; pmid40692561; pmid40660536; pmid40492086; pmid40014480; pmid39884840; pmid39882369; pmid39875497; pmid39857750; pmid39852767; pmid39775762; pmid39741599; pmid39523946; pmid39207648; pmid38585346; pmid38510743; pmid38392604; pmid38240001; pmid38173173; pmid37981644; pmid37654428; pmid37204997; pmid36938206; pmid36732397; pmid36718484; pmid36639608; pmid36611357; pmid36339677; pmid36074973; pmid35891154; pmid35853576; pmid35852546; pmid35470419; pmid35355961; pmid35269395; pmid34821709; pmid34729276; pmid34541421; pmid34192289; pmid34151246; pmid33996867; pmid33869099; pmid33740207'] - [long_covid, associated_with, pots, 'pmid42564177; pmid42512077; pmid42279051; pmid41859298; pmid41300849; pmid41146789; pmid41111962; pmid41089328; pmid41050528; pmid41038948; pmid41025260; pmid41020219; pmid40883051; pmid40864005; pmid40734755; pmid40692561; pmid40660536; pmid40492086; pmid40014480; pmid39919323; pmid39884840; pmid39882369; pmid39875497; pmid39857750; pmid39852767; pmid39838139; pmid39775762; pmid39741599; pmid39554298; pmid39523946; pmid39200375; pmid39198662; pmid39076856; pmid38585346; pmid38392604; pmid38390594; pmid38240001; pmid38173173; pmid37981644; pmid37654428; pmid37435242; pmid37391116; pmid37255928; pmid37204997; pmid37030518; pmid37009342; pmid36938206; pmid36732397; pmid36639608; pmid36611357; pmid36518330; pmid36339677; pmid36074973; pmid35853576; pmid35852546; pmid35470419; pmid35381331; pmid35355961; pmid35269395; pmid34993394; pmid34821709; pmid34729276; pmid34607799; pmid34192289; pmid34151246; pmid33983522; pmid33869099; pmid33740207; pmid42788130; pmid41713697; pmid39043760; pmid38900132; pmid38673062; pmid38469013; pmid37822957; pmid36981522; pmid36718484; pmid36090156; pmid35679657; pmid35241011; pmid34541421; pmid33927679; pmid33786700'] - [long_covid, associated_with, small_fiber_neuropathy_dx, 'pmid39852767'] - [mast_cell_activation, associated_with, me_cfs, 'pmid41300853'] - [mast_cell_activation, associated_with, post_vaccination_onset, 'pmid40729147; pmid35062788'] - [mast_cell_activation, associated_with, postinfectious_evidence, 'pmid41282714; pmid33869099'] - [mast_cell_activation, associated_with, pots, 'pmid41924132; pmid41753313; pmid41668453; pmid41300853; pmid40856938; pmid40729147; pmid40352770; pmid39559520; pmid39200375; pmid39109428; pmid38390594; pmid38003876; pmid37255928; pmid37241210; pmid37234076; pmid36981522; pmid36590760; pmid36252987; pmid35307584; pmid35062788; pmid34928881; pmid34866935; pmid33886735; pmid33178533; pmid32494413; pmid29864098; pmid29523389; pmid29326369; pmid26198889; pmid23753844; pmid16943900; pmid15710782; pmid42153984; pmid41898333; pmid39931100; pmid39165715; pmid38526146; pmid38348221; pmid38269002; pmid36074973; pmid34821709; pmid34398691; pmid33869099; pmid30400667'] - [me_cfs, associated_with, neuropathic_evidence, 'pmid37968647'] - [me_cfs, associated_with, postinfectious_evidence, 'pmid36639608; pmid38600563; pmid33996867; pmid29391028'] - [me_cfs, associated_with, pots, 'pmid42746015; pmid41952073; pmid41932997; pmid41859298; pmid41446482; pmid41300853; pmid41225175; pmid40761644; pmid40365455; pmid38650940; pmid38540980; pmid36611357; pmid36590760; pmid35697326; pmid35689118; pmid35241011; pmid34866935; pmid31159884; pmid30505831; pmid29876157; pmid29391028; pmid28674681; pmid26425598; pmid24934205; pmid24386408; pmid21906029; pmid41050528; pmid40978926; pmid33996867'] - [neuropathic_evidence, associated_with, postinfectious_evidence, 'pmid36718484; pmid36639608'] - [neuropathic_evidence, associated_with, pots, 'pmid41301791; pmid41089328; pmid40271232; pmid39852767; pmid38537312; pmid37009342; pmid36938206; pmid36349067; pmid33490373; pmid29523389; pmid24711524; pmid23708963; pmid19207771; pmid42153984; pmid41767063; pmid40624434; pmid40608783; pmid39200375; pmid37968647; pmid36639608; pmid34055418; pmid33764697; pmid33459162; pmid29864098; pmid29549458; pmid27660311; pmid24819031; pmid24647968; pmid24386408; pmid16943900'] - [neuropathic_evidence, associated_with, small_fiber_neuropathy_dx, 'pmid29523389; pmid40271232; pmid37968647; pmid36349067; pmid33764697'] - [neuropathic_evidence, associated_with, systemic_autoimmune_disease, 'pmid36349067; pmid29864098'] - [physical_trauma_onset, associated_with, pots, 'pmid42369281; pmid40694349; pmid35647216; pmid29864098; pmid20865679'] - [post_vaccination_onset, associated_with, postinfectious_evidence, 'pmid38173801; pmid37204997'] - [post_vaccination_onset, associated_with, pots, 'pmid40729147; pmid35870086; pmid33968543; pmid39538129; pmid39200375; pmid39109119; pmid38176772; pmid38173801; pmid37654428; pmid37650075; pmid37303827; pmid37248893; pmid37204997; pmid36530759; pmid36475233; pmid35937046; pmid35891154; pmid35062788; pmid24102827'] - [postinfectious_evidence, associated_with, pots, 'pmid42512077; pmid41020219; pmid40734755; pmid39857750; pmid39838139; pmid39559520; pmid39202605; pmid39200375; pmid38390594; pmid38173801; pmid37435242; pmid37391116; pmid37204997; pmid37009342; pmid36611357; pmid36339677; pmid35381331; pmid34821709; pmid34192289; pmid33983522; pmid33927679; pmid33740207; pmid32848537; pmid29687025; pmid19058765; pmid42746015; pmid42279051; pmid41859298; pmid41300849; pmid41146789; pmid41089328; pmid41050528; pmid41038948; pmid40883051; pmid40692561; pmid40660536; pmid40492086; pmid40014480; pmid39882369; pmid39852767; pmid39775762; pmid39741599; pmid39554298; pmid38673062; pmid38585346; pmid38240001; pmid38173173; pmid37981644; pmid37822957; pmid37654428; pmid36938206; pmid36732397; pmid36729924; pmid36718484; pmid36703776; pmid36518330; pmid35853576; pmid35852546; pmid35470419; pmid35355961; pmid35269395; pmid35241011; pmid34993394; pmid34729276; pmid34541421; pmid34151246; pmid34144933; pmid31495251; pmid31001074; pmid28738696; pmid28674681; pmid26198889; pmid25087056; pmid24830783'] - [postinfectious_evidence, associated_with, small_fiber_neuropathy_dx, 'pmid39852767'] - [prolonged_bed_rest, associated_with, pots, 'pmid24819031'] - [secondary_sinus_tachycardia, associated_with, pots, 'pmid37009342'] - [sleep_disturbance, associated_with, pots, 'pmid42254140; pmid35742222; pmid35689118; pmid35303039; pmid34866935; pmid33231164; pmid31024242; pmid29773483; pmid29628432; pmid29163944; pmid28442939; pmid27206906; pmid26859225; pmid26695400; pmid26611942; pmid26198889; pmid25071706; pmid23999934; pmid23753844; pmid23538032; pmid22889291; pmid29876157; pmid28769598; pmid25474569'] - [sleep_disturbance, associated_with, surgery_onset, 'pmid22889291'] - [small_fiber_neuropathy_dx, associated_with, pots, 'pmid41301791; pmid40271232; pmid39200375; pmid38537312; pmid37009342; pmid33459162; pmid29523389; pmid41089328; pmid39852767; pmid39559520; pmid37968647; pmid36349067; pmid33764697; pmid24647968; pmid16943900'] - [small_fiber_neuropathy_dx, associated_with, systemic_autoimmune_disease, 'pmid36349067'] - [surgery_onset, associated_with, pots, 'pmid41561794; pmid22889291'] - [systemic_autoimmune_disease, associated_with, pots, 'pmid41952073; pmid41446482; pmid41089328; pmid38673062; pmid37255928; pmid36908200; pmid36816268; pmid36590760; pmid35853576; pmid35288409; pmid35156619; pmid34144933; pmid34055446; pmid29864098; pmid22889291; pmid42299385; pmid39559520; pmid36349067; pmid33244220'] # trigger_of - [autoimmune_evidence, trigger_of, pots, 'pmid33968543; pmid37248893'] - [deconditioning_evidence, trigger_of, pots, 'pmid24819031'] - [hormonal_transition_onset, trigger_of, pots, 'pmid36908200'] - [hypermobility_heds, trigger_of, pots, 'pmid40729147'] - [long_covid, trigger_of, autoimmune_evidence, 'pmid39200375'] - [long_covid, trigger_of, hypovolemic_evidence, 'pmid39200375'] - [long_covid, trigger_of, postinfectious_evidence, 'pmid41275041; pmid39775762; pmid36938206; pmid35853576; pmid34993394; pmid34053992; pmid33786700; pmid33262898; pmid32880754; pmid37204997; pmid35470419'] - [long_covid, trigger_of, pots, 'pmid41275041; pmid40734755; pmid39775762; pmid39200375; pmid38673062; pmid38173173; pmid37204997; pmid36938206; pmid36590760; pmid36575713; pmid36530759; pmid35853576; pmid35056336; pmid34993394; pmid34928881; pmid34053992; pmid33786700; pmid33262898; pmid32880754; pmid39202605; pmid37391116; pmid35470419'] - [mast_cell_activation, trigger_of, pots, 'pmid35062788'] - [physical_trauma_onset, trigger_of, pots, 'pmid35647216; pmid29864098; pmid24819031; pmid20865679'] - [post_vaccination_onset, trigger_of, autoimmune_evidence, 'pmid35870086; pmid33968543; pmid26425598'] - [post_vaccination_onset, trigger_of, hyperadrenergic_evidence, 'pmid35870086'] - [post_vaccination_onset, trigger_of, pots, 'pmid39538129; pmid38673062; pmid37650075; pmid36732397; pmid36530759; pmid36475233; pmid35891154; pmid35725868; pmid35062788; pmid33968543; pmid40729147; pmid39741599; pmid39559520; pmid39109119; pmid38176772; pmid37303827; pmid37248893; pmid37009342; pmid36852364; pmid36718484; pmid35870086; pmid35611338; pmid29876157; pmid26425598; pmid25882168'] - [postinfectious_evidence, trigger_of, pots, 'pmid41275041; pmid40729147; pmid40533427; pmid39875497; pmid39838139; pmid39678714; pmid39552985; pmid38958137; pmid38390594; pmid37822957; pmid37391116; pmid37204997; pmid36938206; pmid35853576; pmid35470419; pmid34993433; pmid34993394; pmid34928881; pmid34144933; pmid33786700; pmid33262898; pmid32880754; pmid29343965; pmid24819031; pmid39775762; pmid38173173; pmid36575713; pmid35056336; pmid34053992; pmid32848537'] - [prolonged_bed_rest, trigger_of, hypovolemic_evidence, 'pmid24819031'] - [prolonged_bed_rest, trigger_of, pots, 'pmid24819031; pmid33623665'] - [surgery_onset, trigger_of, autoimmune_evidence, 'pmid41561794'] - [surgery_onset, trigger_of, pots, 'pmid41561794; pmid40729147; pmid33623665; pmid22889291; pmid39355826'] - [systemic_autoimmune_disease, trigger_of, pots, 'pmid39678714'] # differential_diagnosis_of - [anxiety_depression, differential_diagnosis_of, pots, 'pmid39559520; pmid25156902'] - [arrhythmia_differential, differential_diagnosis_of, pots, 'pmid29523389; pmid37519618; pmid23270259'] - [differential_syncope_oh, differential_diagnosis_of, pots, 'pmid41767063; pmid39741599; pmid39202605; pmid37519618; pmid37248893; pmid37204997; pmid37009342; pmid36938206; pmid36074973; pmid35818599; pmid35742222; pmid35720084; pmid35372154; pmid35288409; pmid34928881; pmid33150760; pmid32222376; pmid27525257; pmid21977261'] - [iron_deficiency, differential_diagnosis_of, pots, 'pmid39559520'] - [medication_induced_tachycardia, differential_diagnosis_of, pots, 'pmid39202605; pmid37009342; pmid30838497'] - [prolonged_bed_rest, differential_diagnosis_of, pots, 'pmid34144933; pmid16943900'] - [secondary_sinus_tachycardia, differential_diagnosis_of, pots, 'pmid39202605; pmid37654428; pmid37519618; pmid37261636; pmid36938206; pmid29523389; pmid16943900; pmid40271232; pmid37204997; pmid37009342; pmid36074973; pmid35870086; pmid30838497'] - [systemic_autoimmune_disease, differential_diagnosis_of, pots, 'pmid24819031'] # measures - [active_stand_test, measures, orthostatic_heart_rate_increment, 'pmid40003288'] - [plasma_blood_volume_assay, measures, intravascular_volume, 'pmid39614968'] # part_of - [active_stand_test, part_of, autonomic_reflex_screen, 'pmid38937334'] - [cerebral_blood_flow_measurement, part_of, orthostatic_challenge_testing, 'pmid26909037'] - [valsalva_maneuver, part_of, autonomic_reflex_screen, 'pmid38937334'] - [valsalva_maneuver, part_of, orthostatic_challenge_testing, 'pmid38937334'] # <<< end of generated links